Korean Circulation Journal

  • 제42권11호
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  • Pages.761-768
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  • 2012
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
권호 표지
DOI QR코드

DOI QR Code

Changes of Gene Expressions in Spontaneously Hypertensive Rat Model After Losartan Treatment

  • Cha, Ji Hei (Department of Pediatrics, Ewha Womans University School of Medicine) ;
  • Lee, Hye Ryon (Department of Pediatrics, Ewha Womans University School of Medicine) ;
  • Kim, Kwan Chang (Department of Thoracic and Cardiovascular Surgery, Ewha Womans University School of Medicine) ;
  • Cho, Min-Sun (Department of Pathology, Ewha Womans University School of Medicine) ;
  • Hong, Young Mi (Department of Pediatrics, Ewha Womans University School of Medicine)
  • 발행 : 2012.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: The renin angiotensin system seems to play an important role in the development of cardiac and vascular hypertrophy in hypertension. The changes in pathology, and gene expressions of the angiotensin II receptor type 1A (ATIA) and angiotensin converting enzyme (ACE) were investigated in order to explore the effects of losartan in spontaneously hypertensive rat (SHR) models. Materials and Methods: Twelve week-old male Wistar rats were grouped as follows: control (C) group, hypertension (H) group, and losartan (L) group in which SHR was treated with losartan (10 mg/kg/day). Western blot and reverse transcription-polymerase chain reaction analysis regarding seven genes such as endothelin-1, ACE, ATIA, neutrophil cytosolic factor, brain natriuretic peptide, troponin I, endothelial nitric oxide synthase were performed. Results: Systolic blood pressure was significantly decreased in the L group compared with the H group in weeks 3 and 5. ACE and ATIA proteins in the L group were lower than H group in week 5. Conclusion: Losartan reduced blood pressure, cardiac hypertrophy and protein expressions of ACE and ATIA. Changes of protein expressions were more sensitive than changes in pathology. Further study is needed for the differing doses of losartan in SHR models.

키워드

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  1. Long-term treatment of spontaneously hypertensive rats with losartan and molecular basis of modulating Ito of ventricular myocytes vol.9, pp.5, 2012, https://doi.org/10.3892/mmr.2014.2001
  2. Changes of blood pressure, abdominal visceral fat tissue and gene expressions in fetal programming induced rat model after amlodipine–losartan combination treatment vol.22, pp.None, 2012, https://doi.org/10.1186/s40885-016-0046-9
  3. Microarray Analysis in Spontaneously Hypertensive Rat Heart after Losartan Treatment vol.39, pp.2, 2012, https://doi.org/10.12771/emj.2016.39.2.45