The Korean Journal of Medicine

  • 제83권5호
  • /
  • Pages.679-682
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  • 2012
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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펜타미딘으로 치료 받은 후천성 면역 결핍증 환자에서 발생한 저혈당 1예

Hypoglycemic Seizures Associated with Pentamidine for Pneumocystis jiroveci Pneumonia in a HIV Patient

  • 최홍석 (건국대학교 의학전문대학원 내과학교실) ;
  • 기현균 (건국대학교 의학전문대학원 내과학교실) ;
  • 송기호 (건국대학교 의학전문대학원 내과학교실) ;
  • 정혜숙 (건국대학교 의학전문대학원 내과학교실) ;
  • 서정웅 (건국대학교 의학전문대학원 내과학교실) ;
  • 정현아 (건국대학교 의학전문대학원 내과학교실) ;
  • 황용 (건국대학교 의학전문대학원 내과학교실)
  • Choi, Hong Seok (Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine) ;
  • Ki, Hyun Kyun (Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine) ;
  • Song, Kee Ho (Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine) ;
  • Cheong, Hae Suk (Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine) ;
  • Seo, Jung Woong (Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine) ;
  • Chung, Hyun Ah (Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine) ;
  • Hwang, Yong (Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine)
  • 발행 : 2012.11.01
⟨ 이전 논문 다음 논문 ⟩

초록

Pentamidine은 폐포자충 폐렴에서 쓰이는 약제로 부작용으로 저혈당이 발생할 수 있다. 저자들은 pentamidine을 21일간 사용한 후천성 면역 결핍증 환자에서 저혈당으로 인한 경련을 국내에서 처음으로 경험하였기에 문헌고찰과 함께 보고한다.

Trimethoprim-sulfamethoxazole (TMX-SMZ) is the initial treatment for Pneumocystis jiroveci pneumonia in human immunodeficiency virus (HIV) patients. About 20% of patients do not complete the TMX-SMZ treatment due to treatment failure or adverse reactions. Pentamidine isethionate has been used for P. jiroveci pneumonia as a second-line regimen. Although hypoglycemia is a common adverse effect of pentamidine, pentamidine-induced hypoglycemia has not been reported in Korea. We present an HIV patient with grand mal seizures caused by pentamidine-induced hypoglycemia who was managed successfully with IV dextrose infusion. Mental changes can occur during pentamidine treatment, but hypoglycemia is often ignored and misdiagnosed as epilepsy or stroke. It can result in seizures, coma, and even death. We should be aware of pentamidine-induced hypoglycemia, which can lead to severe neurologic deficits and diabetes mellitus.

키워드

참고문헌

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