Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
권호 표지
DOI QR코드

DOI QR Code

Congenital Neosporosis in Goats from the State of Minas Gerais, Brazil

  • Varaschin, Mary S. (Departament of Veterinary Medicine, Universidade Federal de Lavras) ;
  • Hirsch, Christian (Departament of Veterinary Medicine, Universidade Federal de Lavras) ;
  • Wouters, Flademir (Departament of Veterinary Medicine, Universidade Federal de Lavras) ;
  • Nakagaki, Karen Y. (Departament of Veterinary Medicine, Universidade Federal de Lavras) ;
  • Guimaraes, Antonio M. (Departament of Veterinary Medicine, Universidade Federal de Lavras) ;
  • Santos, Domingos S. (Departament of Veterinary Medicine, Universidade Federal de Lavras) ;
  • Bezerra, Pedro S. Jr (Departament of Veterinary Medicine, Universidade Federal de Lavras) ;
  • Costa, Rafael C. (Departament of Veterinary Medicine, Universidade Federal de Lavras) ;
  • Peconick, Ana P. (Departament of Veterinary Medicine, Universidade Federal de Lavras) ;
  • Langohr, Ingeborg M. (Michigan State University, Diagnostic Center for Population and Animal Health)
  • Received : 2011.09.14
  • Accepted : 2011.11.03
  • Published : 2012.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Congenital $Neospora$ $caninum$ infection was diagnosed in two Saanen goat kids from two distinct herds with a history of abortion and weak newborn goat kids in the Southern region of the State of Minas Gerais, Brazil. The first kid was weak at birth, had difficulty to rise and was unable to nurse. Gross lesions of porencephaly and hydrocephalus ex vacuo were seen. Multifocal necrosis, gliosis and non-supurative encephalitis were observed in the brain. Several parasitic cysts with a thick wall that reacted strongly only with polyclonal antiserum to $Neospora$ $caninum$ were seen in the cerebral cortex, brain stem and cerebellum. The second kid was born from a $Neospora$ $caninum$ seropositive mother that aborted in the last pregnancy. It was born without clinical signs. The diagnosis of neosporosis was based on antibody titer of 1:800 to $N.$ $caninum$ by indirect fluorescence antibody test obtained from blood collected before the goat kid ingested the colostrum and $Neospora$ $caninum$ DNA was detected by polymerase chain reaction and sequenced from placenta. This is the first report of neosporosis in goats in the southeast region of Brazil.

Keywords

References

  1. Bjerkas I, Mohn SF, Presthus J. Unidentified cyst-forming sporozoon causing encephalomyelitis and myositis in dogs. Z Parasitenkd 1984; 70: 271-274. https://doi.org/10.1007/BF00942230
  2. Dubey JP, Carpenter JL, Speer CA, Topper MJ, Uggla A. Newly recognized fatal protozoan disease of dogs. J Am Vet Med Assoc 1988; 192: 1269-1285.
  3. Dubey JP, Buxton D, Wouda W. Pathogenesis of bovine neosporosis. J Comp Pathol 2006; 134: 267-289. https://doi.org/10.1016/j.jcpa.2005.11.004
  4. Dubey JP. Review of Neospora caninum and neosporosis in animals. Korean J Parasitol 2003; 41: 1-16. https://doi.org/10.3347/kjp.2003.41.1.1
  5. Barr BC, Anderson ML, Woods LW, Dubey JP, Conrad PA. Neospora-like protozoal infections associated with abortions in goats. J Vet Diagn Invest 1992; 4: 365-367. https://doi.org/10.1177/104063879200400331
  6. Corbellini LG, Colodel EM, Driemeier D. Granulomatous encephalitis in a neurologically impaired goat kid associated with degeneration of Neospora caninum tissue cysts. J Vet Diagn Invest 2001; 13: 416-419. https://doi.org/10.1177/104063870101300509
  7. Dubey JP, Morales JA, Villalobos P, Lindsay DS, Blagburn BL, Topper MJ. Neosporosis-associated abortion in a dairy goat. J Am Vet Med Assoc1996; 208: 263-265.
  8. Eleni C, Crotti S, Manuali E, Costarelli S, Filippini G, Moscati L, Magnino S. Detection of Neospora caninum in an aborted goat foetus. Vet Parasitol 2004; 123: 271-274. https://doi.org/10.1016/j.vetpar.2004.06.017
  9. Dubey JP, Schares G. Diagnosis of bovine neosporosis. Vet Parasitol 2006; 140: 1-34. https://doi.org/10.1016/j.vetpar.2006.03.035
  10. Varaschin MS, Guimaraes AM, Hirsch C, Mesquita LP, Abreu CC, Rocha CMBM, Wouters F, Moreira MC. Factors associated to seroprevalence of Neospora caninum and Toxoplasma gondii in caprine herds in southern Minas Gerais state, Brazil. Pesq Vet Bras 2011; 31: 53-58.
  11. Figliuolo LPC, Rodrigues AAR, Viana RB, Aguiar DM, Kasai N, Gennari SM. Prevalence of anti-Toxoplasma gondii and anti-Neospora caninum antibodies in goats from São Paulo State, Brazil. Small Ruminant Res 2004; 55: 29-32. https://doi.org/10.1016/j.smallrumres.2003.12.013
  12. Soldati S, Kiupel M, Wise A, Maes R, Botteron C, Robert N. Meningoencephalomyelitis caused by Neospora caninum in a juvenile fallow deer (Dama dama). J Vet Med A (Physiol Pathol Clin Med) 2004; 51: 280-283. https://doi.org/10.1111/j.1439-0442.2004.00646.x
  13. Costa JRR, Lobato ZIP, Herrmann GP, Leite RC, Haddad JPA. Prevalence of bluetongue virus antibodies in cattle and sheep in southwest and southeast regions of Rio Grande do Sul, Brazil. Arq Bras Med Vet Zootec 2006; 58: 273-275. https://doi.org/10.1590/S0102-09352006000200017
  14. Santos DS. Andrade MP, Varaschin MS, Guimaraes AM, Hirsch C. Neospora caninum in bovine fetuses of Minas Gerais, Brazil: genetic characteristics of rDNA. Rev Bras Parasitol Vet 2011; 20: 281-288. https://doi.org/10.1590/S1984-29612011000400005
  15. Payne S, Ellis J. Detection of Neospora caninum DNA by the polymerase chain reaction. Int J Parasitol 1996; 26: 347-351. https://doi.org/10.1016/0020-7519(96)00030-6
  16. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ, Myers, EW, and Lipman, DJ. Basic local alignment search tool. J Mol Biol 1990; 215: 403-410. https://doi.org/10.1016/S0022-2836(05)80360-2
  17. Jubb KVF, Huxtable CR. The Nervous System. In Jubb KVF, Kennedy PC, Palmer N eds, Pathology of Domestic Animals (Vol. 1). 4th ed. San Diego, USA. Academic Press. 1993, p 267-439.
  18. Underwood EJ, Suttle NF. The mineral nutrition of livestock. 3th ed. CAB International. 1999, p 1-614.
  19. Zachary JF. Nervous System. In MacGavin MD, Zachary JF eds, Pathologic Basis of Veterinary Disease. St. Louis, Missouri, USA. Mosby, Elsevier. 2007, p 833-971.
  20. Clavijo A, Sepulveda L, Riva J, Pessoa-Silva M, Tailor-Ruthes A, Lopez JW, Isolation of bluetongue virus serotype 12 from an outbreak of the disease in South America. Vet Rec 2002; 7: 301-302.
  21. Dubey JP, Lindsay DS. A review of Neospora caninum and neosporosis. Vet Parasitol 1996; 67: 1-59. https://doi.org/10.1016/S0304-4017(96)01035-7
  22. Dubey JP. Epizootic toxoplasmosis associated with abortion in dairy goats in Montana. J Am Vet Med Assoc 1981; 178: 661-670.
  23. Hong CB, Giles RC Jr, Newman LE, Fayer R. Sarcocystosis in an aborted bovine fetus. J Am Vet Med Assoc 1982; 181: 585-588.
  24. Barr BC, Anderson ML, Blanchard PC, Daft BM, Kinde H, Conrad PA. Bovine fetal encephalitis and myocarditis associated with protozoal infections. Vet Pathol 1990; 27: 354-361. https://doi.org/10.1177/030098589002700508
  25. Dubey JP, Davis SW, Speer CA, Bowman DD, de Lahunta A, Granstrom DE, Topper MJ, Hamir AN, Cummings JF, Suter MM. Sarcocystis neurona n. sp. (Protozoa: Apicomplexa), the etiologic agent of equine protozoal myeolencephalitis. J Parasitol 1991; 77: 212-218.
  26. Dubey JP, Barr BC, Barta JR, Bjerkas I, Bjorkman C, Blagburn BL, Bowman DD, Buxton D, Ellis JT, Gottstein B, Hemphill A, Hill DE, Howe DK, Jenkins MC, Kobayashi Y, Koudela B, Marsh AE, Mattsson JG, McAllister MM, Modry D, Omata Y, Sibley LD, Speer CA, Tress AJ, Uggla A, Upton SJ, Williams DJL, Lindsay DS. Redescription of Neospora caninum and its differentiation from related coccidia. Int J Parasitol 2002; 32: 929-946. https://doi.org/10.1016/S0020-7519(02)00094-2

Cited by

  1. Risk factors associated with seroprevalence of Neospora caninum in dogs from urban and rural areas of milk and coffee production in Minas Gerais state, Brazil vol.141, pp.11, 2012, https://doi.org/10.1017/s0950268813000162
  2. Abortos por Neosporacaninum em bovinos do sul de Minas Gerais vol.33, pp.11, 2012, https://doi.org/10.1590/s0100-736x2013001100008
  3. Histological and immunohistochemical characterization of the inflammatory and glial cells in the central nervous system of goat fetuses and adult male goats naturally infected with Neospora caninum vol.10, pp.None, 2012, https://doi.org/10.1186/s12917-014-0291-7
  4. Experimental caprine neosporosis: the influence of gestational stage on the outcome of infection vol.47, pp.None, 2016, https://doi.org/10.1186/s13567-016-0312-6
  5. Caprine Monocytes Release Extracellular Traps against Neospora caninum In Vitro vol.8, pp.None, 2012, https://doi.org/10.3389/fimmu.2017.02016
  6. All about neosporosis in Brazil vol.26, pp.3, 2017, https://doi.org/10.1590/s1984-29612017045
  7. Placental lesions associated with abortion and stillbirth in goats naturally infected by Neospora caninum vol.38, pp.3, 2018, https://doi.org/10.1590/1678-5150-pvb-4598
  8. Serological response to Neospora caninum infection in goats and agreement between three diagnostic techniques to detect caprine neosporosis vol.39, pp.1, 2019, https://doi.org/10.1590/1678-5150-pvb-5989
  9. Evaluation of abortions spontaneously induced by Neospora caninum and risk factors in dairy cattle from Lima, Peru vol.28, pp.2, 2012, https://doi.org/10.1590/s1984-29612019026