Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Scolicidal Effects of $Olea$ $europaea$ and $Satureja$ $khuzestanica$ Extracts on Protoscolices of Hydatid Cysts

  • Zibaei, Mohammad (Division of Parasitology, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences) ;
  • Sarlak, Amanallah (Division of Parasitology, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences) ;
  • Delfan, Bahram (Department of Pharmacology, School of Medicine, Lorestan University of Medical Sciences) ;
  • Ezatpour, Behrouz (Division of Parasitology, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences) ;
  • Azargoon, Alireza (Department of Internal Medicine, Shohaday-e-Ashayer Hospital, Lorestan University of Medical Sciences)
  • Received : 2011.08.11
  • Accepted : 2011.10.30
  • Published : 2012.03.30
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Abstract

Treatment of hydatid disease is mainly surgical, with medical treatment being reserved as a coadjuvant treatment. Use of effective scolicidal agents during surgery of cystic echinococcosis is essential to reduce the recurrence rate. The goal of this study was to evaluate the in vitro scolicidal effects of hydroalcoholic extracts of $Satureja$ $khuzestanica$ leaves and aqueous extracts of $Olea$ $europaea$ leaves on hydatid cyst protoscolices. $Echinococcus$ $granulosus$ protoscolices were collected from the liver of sheep infected with the hydatid cyst. Various concentrations of plant extracts were used in different exposure times for viability assay of protoscolices. Among the olive leaf extracts tested, 0.1% and 0.01% concentrations had strong scolicidal effects in 120 min. $S.$ $khuzestanica$ 0.1% had very strong scolicidal effects in 30, 60, and 120 min of exposure times and the mortality rate decreased with the lower concentration. The finding have shown that the scolicidal activity of $S.$ $khuzestanica$ against cystic echinococosis protoscolices were more effective, while the $O.$ $europaea$ extract showed less effects.

Keywords

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