The human resources of an enterprise is very important in order to survive in these days of business environment. This study investigates the influence of working conditions on organizational effectiveness. Job satisfaction and immersion has been regarded as a key conception of organizational effectiveness. The focus of this study is to investigate the effects of R&D employee's working conditions on organizational effectiveness. The results of this study show that organizational effectiveness are greatly influenced by working conditions. According to the result, First, an enterprise must make a favorable working conditions for R&D employees, the enterprise will provide R&D employees with support for collegiality and good relationship with superiors. Second, the systems of organization are significant in organizational effectiveness. Therefore, the enterprise gives the enterprise's vision and autonomic authority of business to R&D employees in order to improve organizational effectiveness. Finally, the enterprise must admit failure and compensates R&D employees for creative ideas.