Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Effect of 8 Weeks of Aerobic Exercise on Serum Lipids and Kidney Function in Middle-Aged T2DM Patients

8주 유산소 트레이닝이 중년의 제 2형 당뇨(T2DM)환자의 혈청지질 및 신장기능에 미치는 영향

  • Kim, Cheol-Woo (Department of Physical Education, Dong-Eui University) ;
  • Kwak, Yi-Sub (Department of Physical Education, Dong-Eui University) ;
  • Kim, Gun-Do (Department of microbiology, Pukyong University) ;
  • Kim, Young-Il (Department of Sports & Health Management, Youngsan University)
  • 김철우 (동의대학교 체육학과) ;
  • 곽이섭 (동의대학교 체육학과) ;
  • 김군도 (부경대학교 미생물학과) ;
  • 김영일 (영산대학교 스포츠건강관리학과)
  • Received : 2011.12.12
  • Accepted : 2012.01.26
  • Published : 2012.05.30
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Abstract

The purpose of this study was to examine the effect of 8 weeks of aerobic exercise on serum lipids and kidney function in middle-aged T2DM patients. Subjects participated in aerobic exercise training during 8 wk. They started with an exercise intensity of $HR_{max}$ 60-75%, 20~45 minutes per day, 3~5 times a week. The results were compared to the baseline after 8 weeks. After the 8-week aerobic exercise routine, the body fat percentage and fasting glucose were significantly decreased, and the total cholesterol (TC) andtriglycerides (TG) were significantly decreased. Additionally, kidney function (Blood Urea Nitrogen (BUN], uric acids, and creatinine) was not significantly changed. In conclusion, a regular 8-week aerobic exercise training routine may improve serum lipids; however, kidney function (BUN, uric acids, and creatinine) did not change in middle-age type 2 diabetes mellitus (T2DM) and T2DM in diabetic nephropathy patients.

본 연구의 목적은 8주 유산소 트레이닝이 제 2형 당뇨(T2DM)환자의 콜레스테롤과 신장기능에 미치는 영향을 규명하기 위함이다. 피험자는 총 4명(남 3, 여 1)이며 8주 유산소 걷기 트레이닝의 운동강도는 최대심박수($HR_{max}$)의 60~75%, 주당 3~5 회, 20~45 분간 실시되었으며 다음과 같은 결과를 얻었다. 신체적 특성 중 체지방률과 공복시 혈당은 8주 유산소 걷기 트레이닝 후 유의하게($p$ <0.05) 감소함을 나타냈고, 혈중지질인 총 콜레스테롤(TC)과 중성지방(TG)도 유의한 감소를 나타냈다. 그러나 신장기능[BUN, uric acids, creatinine]은 유의한 변화를 나타내지 못했다. 결과적으로 8주 유산소 트레이닝은 제 2형 당뇨(T2DM)와 당뇨병성 신증 환자의 1예에서 체지방률과 공복시혈당, 지질을 감소시키는데 영향을 미쳤지만 신장기능 증진에는 어떠한 영향도 미치지 못했다.

Keywords

References

  1. Choi, D. G. 2004. Effects of regular walking and dietary on the weight, blood glucose, insulin sensitivity, and cell's morphology in the pancreas, kidney, liver of streptozotocin -diabetic rats, and activities of antioxidant enzymes. Department of physical education Graduate School, Kyung-Hee University, Seoul, Korea.
  2. Choi, Y. K. and Lee, T. H. 1995. Diabetics and hyperlipidermia. pp. 111-113, Medical press, Seoul Korea
  3. Derubertis, F. R. and Craven, P. A. 1994. Activation of protein kinase C in glomerular cells in diabetes. Mechanism and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 43, 1-8. https://doi.org/10.2337/diabetes.43.1.1
  4. Han, H. J. 2004. The effect of 12 weeks endurance exercise training on carriers in blood. Exercise Science 13, 15-24.
  5. Hatunic, M., Finucane, F., Burns, N. Gasparro, D. and Nolan, J. J. 2007. Vascular inflammatory markers in early-onset obese and type 2 diabetes subjects before and after three months' aerobic exercise training. Diab. Vasc. Dis. Res. 4, 231-234.
  6. Herman, W. H. and Greene, D. A. 1996. Microvascular complications of diabetes. In Haire-Joshu, D. (ed.), Management of diabetes mellitus perspectives of care across the life span (2nd eds.), pp. 232-280, St. Louis, MO: Mosby.
  7. Jeong, I, S., Gill, G. S., Shin, Y. S., Kim, Y. S. and Lee, S. Y. 2006. Diagnosis-related characteristic of microvascular complications patients with type 2 diabetes mellitus. J. Kor. Acad. Fam. Med. 27, 456-462.
  8. Kadoglou, N. P., Iliadis, F., Angelopoulou, N., Sailer, N., Fotiadis, G., Voliotis, K., Vitta, I., Liapis, C. D. and Alevizos, M. 2008. Cardiorespiratory capacity is associated with favourable cardiovascular risk profile in patients with Type 2 diabetes. J. Diabetes Complications 22, 1-7. https://doi.org/10.1016/j.jdiacomp.2006.10.003
  9. Kim, J. O. 2004. Effect of exercise intensity on function & morphological changes in kidney of streptozotocin-induced diabetic rat. Korean Sport Res. 15, 1007-1016.
  10. Kim, S. H. 2002. Effect of renal function on distance running. Korean J. Physical Edu. 41, 351-362.
  11. Klapcinska, B., Iskra, J., Poprzecki, S. and Grzesiok, K. 2001. The effects of sprint (300 m) running on plasma lactate, uric acid, creatine kinase and lactate dehydrogenase in competitive hurdlers and untrained men. J. Sports Med. Phys. Fitness 241, 306-311.
  12. Lamont, L. S., Lemon, P. W. and Bruot, B. C. 1987. Menstrual cycle and exercise effects on protein catabolism. Med. Sci. Sports Exerc. 19, 106-110.
  13. Lee, Y. K., Kim, C. J., Pyo, H., Kim, C. H. and Ji, J. W. 2001. Endurance exercise training before hemodialysis : An effective therapeutic modality for end-stage renal disease patients. Korean J. Physical Nephrol. 20, 290-297.
  14. Mashiko, T., Umeda, T., Nakaji, S. and Sugawara, K. 2004. Effects of exercise on the physical condition of college rugby players during summer training camp. Br. J. Sports Med. 38, 186-190. https://doi.org/10.1136/bjsm.2002.004333
  15. Spellman, C. W. 2008. Aggressively managing type 2 diabetes mellitus, hyperlipidemia, and bone loss. J. Am Osteopath. Assoc. 108, S20-27.
  16. Svacinova, H., Novakova, M., Placheta, Z., Kohzuki, M., Nagasaka, M., Minami, N., Dobsak, P. and Siegelova, J. 2008. Benefit of combined cardiac rehabilitation on exercise capacity and cardiovascular parameters in patients with type 2 diabetes. Tohoku J. Experimental Medicine 215, 103-111. https://doi.org/10.1620/tjem.215.103
  17. World Health Organization. 2007. Prevalence of diabetes worldwide page. Available at: www.who.int/diabetes/facts/world_figures/en.
  18. Yoon, W. S., Shin, E. L. and Park, D. H. 2001. Effect of the prolonged oral creatin supplementation on muscle and liver function and muscular strength. J. Sport Leisure Studies 16, 593-605.