Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Microwave Ablation Treatment of Liver Cancer with a 2,450-MHz Cooled-shaft Antenna: Pilot Study on Safety and Efficacy

  • Jiao, De-Chao (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Zhou, Qi (Department of Hepatobiliary Surgery, The First Affiliated Hospital of SunYat-sen University) ;
  • Han, Xin-Wei (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Wang, Ya-Feng (Department of Hepatobiliary Surgery, The First Affiliated Hospital of SunYat-sen University) ;
  • Wu, Gang (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Ren, Jian-Zhuang (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Wang, Yan-Li (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Ding, Peng-Xu (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Ma, Ji (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Fu, Ming-Ti (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University)
  • Published : 2012.02.29
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Abstract

To evaluate efficacy of microwave ablation in a primary clinical study, sixty patients (44 men, 16 women; mean age 53 years) with 96, 1-8 cm (mean $3.20{\pm}0.17$ cm) liver cancers were treated with 2,450-MHz internally cooled-shaft antenna. Complete ablation (CA) and local tumor progression (LTP) rates as well as complications were determined. CA rates in small (< 3.0 cm), intermediate (3.1-5.0 cm) and large (5.1-8.0 cm) liver cancers were 96.4% (54/56), 92.3% (24/26) and 78.6% (11/14), respectively. During a mean follow-up period of $17.17{\pm}6.52$ months, LTP occurred in five (5.21%) treated cases. There was no significant difference in the CA and LTP rates between the HCC and liver metastasis patient subgroups (P<0.05). Microwave ablation provides a reliable, efficient, and safe technique to perform hepatic tumor ablation.

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References

  1. Abe T, Shinzawa H, Wakabayashi H, et al (2000). Value of laparoscopic microwave coagulation therapy for hepatocellular carcinoma in relation to tumor size and location. Endoscopy, 32, 598-603. https://doi.org/10.1055/s-2000-9016
  2. Cabassa P, Donato F, Simeone F, Grazioli L, Romanini L (2006). Radiofrequency ablation of hepatocellular carcinoma: longterm experience with expandable needle electrodes. AJR Am J Roentgenol, 186, S316-21. https://doi.org/10.2214/AJR.05.0243
  3. Chen MH, Yang W, Yan K, et al (2004). Large liver tumors: protocol for radiofrequency ablation and its clinical application in 110 patients- mathematic model, over-lapping mode, and electrode placement process. Radiology, 232, 260-71. https://doi.org/10.1148/radiol.2321030821
  4. Clasen S, Schmidt D, Boss A, et al (2006). Multipolar radiofrequency ablation with internally cooled electrodes: experimental study in ex vivo bovine liver with mathematic modeling. Radiology, 238, 881-90. https://doi.org/10.1148/radiol.2382050571
  5. Dib RE, Touma NJ, Kapoor A (2009). Review of the efficacy and safety of radiofrequency ablation for the treatment of small renal masses. Can Urol Assoc J, 3, 143-9.
  6. Dong BW, Liang P, Yu XL, et al (1998). Sonographically guided microwave coagulation treatment of liver cancer: an experimental and clinical study. AJR Am J Roentgenol, 171, 449-54. https://doi.org/10.2214/ajr.171.2.9694473
  7. Dong BW, Liang P, Yu X,et al (2003). Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: results in 234 patients. AJR Am J Roentgenol, 180, 1547-55. https://doi.org/10.2214/ajr.180.6.1801547
  8. English NJ, MacElroy JM(2003). Molecular dynamics simulations of microwave heating of water. J Chem Phys, 118, 1589-1592. https://doi.org/10.1063/1.1538595
  9. Goldberg SN, Ahmed M, Gazelle GS, et al (2001). Radiofrequency thermal ablation with NaCl solution injection: effect of electrical conductivity on tissue heating and coagulation-phantom and porcine liver study. Radiology, 219, 157-65. https://doi.org/10.1148/radiology.219.1.r01ap27157
  10. Goldberg SN, Gazelle GS, Mueller PR (2000). Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. Am J Roentgenol, 174, 323-31. https://doi.org/10.2214/ajr.174.2.1740323
  11. Hadjicostas P, Malakounides N, Varianos C, et al (2006). Radiofrequency ablation in pancreatic cancer. HPB (Oxford), 8, 61-4. https://doi.org/10.1080/13651820500466673
  12. Hines-Peralta AU, Pirani N, Cleqq P, et al (2006). Microwave ablation: results with a 2.45-GHz applicator in ex vivo bovine and in vivo porcine liver. Radiology, 230, 94-102.
  13. Imoto S, Wada N, Sakemura N, Hasebe T, Murata Y (2009). Feasibility study on radiofrequency ablation followed by partial mastectomy for stage I breast cancer patients. Breast, 18, 130-4. https://doi.org/10.1016/j.breast.2009.02.008
  14. Lencioni R, Cioni D, Crocetti L, et al (2005). Earlystage hepatocellular carcinoma in patients with cirrhosis: longterm results of percutaneous image-guided radiofrequency ablation. Radiology, 234, 961-7. https://doi.org/10.1148/radiol.2343040350
  15. Liang P, Dong B, Yu X, et al (2003). Prognostic factors for percutaneous microwave coagulation therapy of hepatic metastases. AJR Am J Roentgenol, 181, 1319-25. https://doi.org/10.2214/ajr.181.5.1811319
  16. Liang P, Dong B, Yu X, et al (2005). Prognostic factors for survival inpatients with hepatocellular carcinoma after percutaneous microwave ablation. Radiology, 181, 299-307.
  17. Lu MD, Chen JW, Xie XY, et al (2001). Hepatocellular carcinoma: US-guided percutaneous microwave coagulation therapy. Radiology, 221, 167-72. https://doi.org/10.1148/radiol.2211001783
  18. Martin RC, Scoggins CR, McMasters KM (2007). Mcirowave hepatic ablation: initial experience of safety and efficacy. J of Surg Oncol, 96, 481-6. https://doi.org/10.1002/jso.20750
  19. Ng KK, Lam CM, Poon RT, et al (2005). Porcine liver: morphologic characteristics and cell viability at experimental radiofrequency ablation with internally cooled electrodes. Radiology, 235, 478-86. https://doi.org/10.1148/radiol.2352040425
  20. Shibata T, Maetani Y, Isoda H, Hiraoka M (2006). Radiofrequency ablation for small hepatocellular carcinoma: prospective comparison of internally cooled electrode and expandable electrode. Radiology, 238, 346-53. https://doi.org/10.1148/radiol.2381041848
  21. Ohno T, Kawano K, Sasaki A, et al (2001). Expansion of an ablated site and induction of apoptosis after microwave coagulation therapy in rat liver. J Hepatobiliary Pancreat Surg, 8, 360-6. https://doi.org/10.1007/s005340170009
  22. Ozaki T, Mori I, Nakamura M, et al (2003). Microwave cell death: immunohistochemical and enzyme histochemical evaluation. Pathol Int, 53, 686-92. https://doi.org/10.1046/j.1440-1827.2003.01537.x
  23. Pacella CM, Bizzarri G, Francica G, et al (2005). Percutaneous laser ablation in the treatment of heaptocellular carcinoma with small tumors: analysis of factors affecting the achievement of tumor necrosis. J Vasc Interv Radiol, 16, 1427-57. https://doi.org/10.1097/01.RVI.0000188755.61481.E8
  24. Pua BB, Solomon SB (2009). Radiofrequency ablation of primary and metastatic lung cancers. Semin Ultrasound CT MR, 30, 113-24. https://doi.org/10.1053/j.sult.2008.12.001
  25. Rasekhi AR, Naderifar M, Bagheri MH, et al (2009). Radiofrequency ablation of the spleen in patients with thalassemia intermedia: a pilot study. Am J Roentgenol, 192, 1425-9. https://doi.org/10.2214/AJR.08.1382
  26. Shock SA, Meredith K, Warner TF, et al (2004). Microwave ablation with loop antenna: in vivo porcine liver model. Radiology, 231, 143-9. https://doi.org/10.1148/radiol.2311021342
  27. Tateishi R, Shiina S, Teratani T, et al (2005). Percutaneous radiofrequency ablation for hepatocellular carcinoma: an analysis of 1000 cases. Cancer, 103, 1201-9. https://doi.org/10.1002/cncr.20892
  28. Wright AS, Lee FT Jr, Mahvi DM (2003). Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol, 10, 275-83. https://doi.org/10.1245/ASO.2003.03.045
  29. Wright AS, Sampson LA, Warner TF, Mahvi DM, Lee Jr (2005). Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology, 236, 132-9. https://doi.org/10.1148/radiol.2361031249
  30. Yang WZ, Jiang N, Huang N, et al (2009). Combined therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation for small hepatocellular carcinoma. World J Gastroenterol, 14, 748-52.
  31. Yin XY, Xie XY, Lu MD, et al (2009). Percutaneous thermal ablation of medium and large hepatocellular carcinoma. Cancer, 115, 1914-23. https://doi.org/10.1002/cncr.24196

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