Journal of Korean Ophthalmic Optics Society (한국안광학회지)

The Korean Ophthalmic Optics Society (한국안광학회)
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Associations of Metabolic Syndrome with Glaucoma in Korean - Based on the Korean National Health and Nutrition Examination Survey 2005, 2007-9, 2010

한국인의 대사증후군과 녹내장 간의 상관관계 -2005, 2007-9, 2010국민건강영양조사 이용

  • Park, Sang Shin (Dept. of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University) ;
  • Kim, Taehun (Graduate School of Public Health and Institute of Health and Environment, Seoul National University) ;
  • Pak, Yun-Suk (Graduate School of Public Health and Institute of Health and Environment, Seoul National University) ;
  • Lee, Sang-Yoon (Dept. of Preventive Medicine, Kangwon National University) ;
  • Lee, Hae Jung (Nutrition Policy Team, Korea Health Industry Development Institute) ;
  • Lee, Eun-Hee (Dept. of Visual Optics and Graduate School of Health Science, Far East University)
  • 박상신 ;
  • 김태훈 (서울대학교 보건대학원 및 보건환경연구소) ;
  • 박윤숙 (서울대학교 보건대학원 및 보건환경연구소) ;
  • 이상윤 (강원대학교 의과대학 예방의학교실) ;
  • 이해정 (한국보건산업진흥원 영양정책팀) ;
  • 이은희 (극동대학교 안경광학과 및 보건과학대학원)
  • Received : 2012.05.02
  • Accepted : 2012.06.16
  • Published : 2012.06.30
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Abstract

Purpose: This study was conducted to assess the association of metabolic syndrome and its components with glaucoma. Methods: We investigated the associations of metabolic syndrome and its components (abdominal obesity, impaired fasting glucose, high blood pressure, and dyslipidemia) with glaucoma using data from 19,162 adults aged 40 or above among the Korean National Health and Nutrition Examination Survey III (2005), IV (2007-9), V (2010). The logistic regression analysis was used for assessing those associations after adjusting demographic, lifestyle, and social economic status and for assessing the association of metabolic medication intakes with glaucoma risks. Results: After adjusting for age and sex, the risk of glaucoma was significantly higher in the subjects with impaired fasting glucose(Odds Ratio (95% confidence interval): 1.78 (1.25, 2.53)) and metabolic syndrome (1.45 (1.01, 2.08)) than subjects without those. These associations increased when additional adjusting for smoking, alcohol use, regular physical activity, income, education status(impaired fasting glucose: 1.89 (1.29, 2.77), metabolic syndrome: 1.52 (1.03, 2.25)). Glaucoma prevalence was borderline significantly increased according to the number of metabolic abnormalities(age and sex adjusted p for trend = 0.055). Use of antihypertensive medication was significantly associated with the risk of glaucoma. Conclusions: Metabolic syndrome and impaired fasting glucose were significantly associated with the increased glaucoma risk. Use of antihypertensive medication was also significantly associated with the increased glaucoma risk.

목적: 본 연구는 녹내장과 대사증후군, 그리고 구성요소간의 상관성을 평가하기 위해 수행되었다. 방법: 제 3기(2005), 4기(2007-9), 5기(2010) 국민건강영양조사 자료에서 40세 이상 19,162 명을 대상으로 녹내장과 대사증후군, 그리고 구성요소(복부비만, 공복혈당장애, 높은 혈압, 이상지질혈증) 간의 연관성을 조사하였다. 로지스틱회귀분석을 통하여 인구학적, 생활방식 그리고 사회경제적 요인을 보정한 후 연관성을 평가하였으며, 녹내장의 위험과 대사약물복용간의 연관성을 평가하였다. 결과: 성별 및 연령을 보정한 로지스틱 회귀분석에서, 공복혈당장애(odds ratio (95% Confidence Interval): 1.78 (1.25, 2.53)) 및 대사증후군(1.45 (1.01, 2.08))이 있는 연구대상자가 그렇지 않은 연구대상자에 비해 유의하게 높은 녹내장 교차비를 보였고, 추가적으로 흡연, 음주, 규칙적 운동, 소득, 교육수준을 보정하였을 때 교차비는 더욱 증가하는 것으로 나타났다(공복혈당장애: 1.89 (1.29, 2.77), 대사증후군: 1.52 (1.03, 2.25)). 또한, 연구대상자가 가지고 있는 이상 대사증후군 요소의 수에 따른 녹내장의 유병률 증가는 경계적 유의성(borderline significant: age and sex adjusted p for trend = 0.055)을 보였다. 고혈압 치료제의 사용 역시 녹내장의 위험과 유의한 상관관계가 있었다. 결론: 대사증후군 및 공복혈당장애는 녹내장과 유의한 상관관계가 있었고, 고혈압 치료제 사용 역시 녹내장과 유의한 상관관계가 있었다.

Keywords

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