YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Comparison of the Antidepressant Activity of Cirsii herbal Extracts Collected from 5 Different Regions of Korea Determining the Optimal Herbal Preparation

원료 생약 추출물의 최적화를 위한 한국 5개 지역에서 채집된 대계 추출물들의 항우울 효과 비교

  • Lee, Hye Lim (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • dela Pena, June Bryan I. (Department of Pharmacy, College of Pharmacy, Sahmyook University) ;
  • Yoon, Seo Young (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Kim, Seong Mok (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Hong, Eunyoung (Foods R&D, CJ Cheil Jedang Corporation) ;
  • Lee, Yong Soo (Department of Pharmacy, College of Pharmacy, Duksung Women's University) ;
  • Jang, Miran (Department of Food and Nutrition, Duksung Women's University) ;
  • Kim, Gun-Hee (Department of Food and Nutrition, Duksung Women's University) ;
  • Cheong, Jae Hoon (Department of Pharmacy, College of Pharmacy, Sahmyook University)
  • 이혜림 (삼육대학교 약학대학 약학과) ;
  • 준브라이언 (삼육대학교 의명신경과학연구소) ;
  • 윤서영 (삼육대학교 약학대학 약학과) ;
  • 김성목 (삼육대학교 약학대학 약학과) ;
  • 홍은영 (CJ제일제당(주) 식품연구소) ;
  • 이용수 (덕성여자대학교 약학대학) ;
  • 장미란 (덕성여자대학교 식품영양학과) ;
  • 김건희 (덕성여자대학교 식품영양학과) ;
  • 정재훈 (삼육대학교 의명신경과학연구소)
  • Received : 2012.09.05
  • Accepted : 2012.12.28
  • Published : 2012.12.31
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Abstract

Previously, we identified that Cirsium japonicum (CJ) extract posses antidepressant properties. In order to look for the optimal hebal preparation, CJ extracts collected from Koheung, Yesan, Cheju, Pyungchang and Pocheon were compared. The psychopharmacological activities of each extract were investigated using the open field test, the rota-rod test and the forced swimming test. Effect of each extract on $Cl^-$ influx in neuroblastoma cells were also identified. All of the extracts were orally administered at dosages of 50, 100, 200, 400 mg/kg of body weight. Supplementation of CJ did not significantly alter psychomotor behaviors such as movement, rearing frequency and total turn angle on the open field. Supplementation of CJ's extract from Pyungchang (100 mg/kg, p.o.), Cheju (200 and 400 mg/kg p.o.) and Yesan (100 and 200 mg/kg, p.o.) significantly decreased immobile duration and increased mobile duration in the forced swimming test. All of extracts have no influence on NE uptake in HEK-293 cells, but increased $Cl^-$ influx in neuroblastoma cell. The extract from Yesan demonstrated the most potent effect on $Cl^-$ influx. These results indicate that CJ's extracts from Pyungchang, Cheju and Yesan may alleviate depression, and the extract from Yesan may be the most effective preparation.

Keywords

References

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