YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis and Biological Evaluation of Militarin Derivatives

밀리타린 유도체의 합성 및 생리활성 평가

  • Che, Haiyan (College of Pharmacy, Kangwon National University) ;
  • Yoon, Deok Hyo (College of Natural Sciences of Kangwon National University) ;
  • Kim, Tae Woong (College of Natural Sciences of Kangwon National University) ;
  • Sung, Gi-Ho (Rural Development Administration) ;
  • Park, Haeil (College of Pharmacy, Kangwon National University)
  • Received : 2012.10.04
  • Accepted : 2012.12.07
  • Published : 2012.12.31
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Abstract

Militarin was isolated from Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom and reported to possess anticancer activities against several tumor cells. A number of militarin derivatives bearing different numbers of ethylene glycol unit were synthesized and evaluated for their biological activities related with anticancer and antiinflammatory effects. Among militarin derivatives tested, the compounds 2 and 5 exhibited anticancer and antiinflammatory activities.

Keywords

References

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