Pediatric Gastroenterology, Hepatology & Nutrition

  • 제15권1호
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  • Pages.1-7
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  • 2012
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  • 2234-8646(pISSN)
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  • 2234-8840(eISSN)
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)
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Noroviruses: Recent Updates

  • Chung, Ju-Young (Department of Pediatrics, Saggyepaik Hospital, Inje University College of Medicine)
  • 투고 : 2012.03.13
  • 심사 : 2012.03.14
  • 발행 : 2012.03.30
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초록

Noroviruses (NoVs) are one major etiologic agent in acute gastroenteritis (AGE) in all ages and are the primary cause of food-borne gastroenteritis worldwide. GII-4 NoVs has predominated since 1990s, and novel recombinant strains have been reported worldwide. Researchers face difficulties in making vaccines and therapeutic agents against NoVs due to the lack of cell culture and animal-model systems and the rapid emergence of novel variant strains. Recently, a randomized clinical trial for intranasal NoVs vaccine has been reported, which casts a light in the way of vaccine production. This review discusses the recent findings on the structure, immunity, and vaccination of NoVs.

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참고문헌

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