Korean Journal of Otorhinolaryngology-Head and Neck Surgery

Korean Society of Otolaryngology-Head and Neck Surgery (대한이비인후과학회)
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A Case of Oncocytic Carcinoma Arising in the Submandibular Gland

악하선에 발생한 호산성 세포암종 1예

  • Shin, Seung-Kuk (Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine) ;
  • Lee, Young-Ok (Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine) ;
  • Lee, Byung-Joo (Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine) ;
  • Lim, Yun-Sung (Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine)
  • 신승국 (부산대학교 의학전문대학원 이비인후과학교실) ;
  • 이영옥 (부산대학교 의학전문대학원 이비인후과학교실) ;
  • 이병주 (부산대학교 의학전문대학원 이비인후과학교실) ;
  • 임윤성 (부산대학교 의학전문대학원 이비인후과학교실)
  • Received : 2011.07.28
  • Accepted : 2011.10.27
  • Published : 2012.03.25
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Abstract

Oncocytic neoplasm of the head and neck region accounts for approximately 1% of all salivary gland tumors, but only 5% of oncocytic neoplasm is malignant. Oncocytic carcinoma arising in the submandibular gland is exceedingly rare. We encountered a sixty seven-year-old male patient who presented with multiple mass in the right neck. Fine needle aspiration biopsy revealed a salivary gland tumor of predominantly oncocytic form, and a differential diagnosis included oncocytic adenoma or mucoepidermoid carcinoma. A right submandibular gland resection and modified radical neck dissection were performed. Histologically, the tumor cells showed nuclear pleomorphism, and stromal invasion, which were compatible with oncocytic carcinoma. After surgery, the entire neck region was irradiated. Seventeen months after the initial surgery, multiple metastases to the bone and lung were detected from the incidental pathologic bone fracture of the right humerus; palliative chemotherapy was performed to resolve this. We report a case of oncocytic carcinoma in the submandibular gland with a review of literature.

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