Journal of the Korean Society for Precision Engineering (한국정밀공학회지)

Korean Society for Precision Engineering (한국정밀공학회)
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The Effects of Partial Vibration on Tibia of Osteoporosis Induced Rat

골다공증이 유발된 쥐 정강이뼈에 적용한 부분 진동자극 효과

  • Park, Ji-Hyung (Department of Biomedical Engineering & Institute of Medical Engineering, Yonsei Univ. & Yonsei-Fraunhofer Medical Device lab.) ;
  • Seo, Dong-Hyun (Department of Biomedical Engineering & Institute of Medical Engineering, Yonsei Univ. & Yonsei-Fraunhofer Medical Device lab.) ;
  • Jung, Young-Jin (Department of Biomedical Engineering & Institute of Medical Engineering, Yonsei Univ. & Yonsei-Fraunhofer Medical Device lab.) ;
  • Ko, Chang-Yong (Department of Biomedical Engineering & Institute of Medical Engineering, Yonsei Univ. & Yonsei-Fraunhofer Medical Device lab.) ;
  • Kim, Han-Sung (Department of Biomedical Engineering & Institute of Medical Engineering, Yonsei Univ. & Yonsei-Fraunhofer Medical Device lab.)
  • 박지형 (연세대학교 의공학과, 의료공학원구원, 연세대학교-프라운호퍼 의료기기 공동연구센터) ;
  • 서동현 (연세대학교 의공학과, 의료공학원구원, 연세대학교-프라운호퍼 의료기기 공동연구센터) ;
  • 정영진 (연세대학교 의공학과, 의료공학원구원, 연세대학교-프라운호퍼 의료기기 공동연구센터) ;
  • 고창용 (연세대학교 의공학과, 의료공학원구원, 연세대학교-프라운호퍼 의료기기 공동연구센터) ;
  • 김한성 (연세대학교 의공학과, 의료공학원구원, 연세대학교-프라운호퍼 의료기기 공동연구센터)
  • Received : 2011.09.05
  • Accepted : 2012.01.02
  • Published : 2012.05.01
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Abstract

The pharmacological therapies and whole body vibration as non-pharmacological therapies were known to have adverse side effects. Therefore, partial stimulation was suggested and its effects were evaluated. This study aimed to evaluate the site-specific effects of partial stimulator for treatment of osteoporosis induced by estrogen deficiency. Sixteen virginal Sprague-Dawley rats (12 weeks old) were divided into 2 groups(no stimulation, stimulation groups). All rats were ovariectomised to induce osteoporosis. After 3 weeks of operation, the right tibiae in rats of stimulation group (frequency: 10Hz, cycle: 1500, strain on bone surface: $2000{\mu}{\varepsilon}$) were stimulated perpendicularly at right tibia by using partial stimulator for 6 weeks (3days/week). The right tibiae in rats were scanned, before stimulation (0 week) and at 6 weeks after stimulation by using in-vivo micro computed tomography. For investigation of changes in morphological characteristics, structural parameters were measured and calculated. At 6 weeks the morphological characteristics (relative value) in stimulation group were significantly enhanced than those in no stimulation group (p<0.05). In this study, we find that after 6 weeks of partial stimulation, the morphological characteristics of tibia trabecular bone were enhanced. Thus, we concluded that partial stimulation could be used to treat osteoporosis.

Keywords

References

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