Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Outcome of allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia in second complete remission: a single institution study

  • Lee, Eun-Jung (Department of Pediatrics, The Catholic University of Korea, School of Medicine) ;
  • Han, Ji-Yoon (Department of Pediatrics, The Catholic University of Korea, School of Medicine) ;
  • Lee, Jae-Wook (Department of Pediatrics, The Catholic University of Korea, School of Medicine) ;
  • Jang, Pil-Sang (Department of Pediatrics, The Catholic University of Korea, School of Medicine) ;
  • Chung, Nack-Gyun (Department of Pediatrics, The Catholic University of Korea, School of Medicine) ;
  • Jeong, Dae-Chul (Department of Pediatrics, The Catholic University of Korea, School of Medicine) ;
  • Cho, Bin (Department of Pediatrics, The Catholic University of Korea, School of Medicine) ;
  • Kim, Hack-Ki (Department of Pediatrics, The Catholic University of Korea, School of Medicine)
  • Received : 2011.09.15
  • Accepted : 2011.11.14
  • Published : 2012.03.15
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Abstract

Purpose: The survival rate for childhood acute lymphoblastic leukemia (ALL) has improved significantly. However, overall prognosis for the 20 to 25% of patients who relapse is poor, and allogeneic hematopoietic stem cell transplantation (HSCT) offers the best chance for cure. In this study, we identified significant prognostic variables by analyzing the outcomes of allogeneic HSCT in ALL patients in second complete remission (CR). Methods: Fifty-three ALL patients (42 men, 79%) who received HSCT in second CR from August 1991 to February 2009 were included (26 sibling donor HSCTs, 49%; 42 bone marrow transplantations, 79%). Study endpoints included cumulative incidence of acute and chronic graft-versus-host disease (GVHD), relapse, 1-year transplant-related mortality (TRM), disease-free survival (DFS), and overall survival (OS). Results: Cumulative incidences of acute GVHD (grade 2 or above) and chronic GVHD were 45.3% and 28.5%, respectively. The estimated 5-year DFS and OS for the cohort was $45.2{\pm}6.8%$ and $48.3{\pm}7%$, respectively. Only donor type, i.e., sibling versus unrelated, showed significant correlation with DFS in multivariate analysis ($p$=0.010). The rates of relapse and 1 year TRM were $28.9{\pm}6.4%$ and $26.4{\pm}6.1%$, respectively, and unrelated donor HSCT ($p$=0.002) and HLA mismatch ($p$=0.022) were significantly correlated with increased TRM in univariate analysis. Conclusion: In this single institution study spanning more than 17 years, sibling donor HSCT was the only factor predicting a favorable result in multivariate analysis, possibly due to increased TRM resulting from unrelated donor HSCT.

Keywords

References

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