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  • 제12권5호
  • /
  • Pages.213-216
  • /
  • 2012
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Polyacetylene Compound from Cirsium japonicum var. ussuriense Inhibited Caspase-1-mediated IL-$1{\beta}$ Expression

  • Shim, Hong (Institute of Chronic Disease, Sahmyook University) ;
  • Moon, Jung Sun (Traditional Medicines Research Institute, Sahmyook University) ;
  • Lee, Sookyeon (Traditional Medicines Research Institute, Sahmyook University) ;
  • Yim, Dongsool (Traditional Medicines Research Institute, Sahmyook University) ;
  • Kang, Tae Jin (Institute of Chronic Disease, Sahmyook University)
  • 투고 : 2012.09.11
  • 심사 : 2012.09.25
  • 발행 : 2012.10.31
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초록

Our previous report showed that polyacetylene compound, 1-Heptadecene-11, 13-diyne-8, 9, 10-triol (PA) from the root of Cirsium japonicum var. ussuriense has anti-inflammatory activity. In this study we investigated the role of the PA as inhibitor of caspase-1, which converts prointerleukin-$1{\beta}$ (proIL-$1{\beta}$) to active IL-$1{\beta}$ and is activated by inflammasome involved in the inflammatory process. We tested the effect of PA on the production of pro-inflammatory cytokines, IL-$1{\beta}$ in murine macrophage cell line, RAW264.7. PA inhibited lipopolysaccharide (LPS)-induced IL-$1{\beta}$ production by macrophages at a dose dependent manner. PA also suppressed the activation of caspase-1. The mRNA level of ASC (apoptosis-associated spec-like protein containing a CARD), an important adaptor protein of inflammasome, was decreased in the PA treated group. Therefore our results suggest that the anti-inflammatory effect of PA is due to inhibit the caspase-1 activation.

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과제정보

연구 과제 주관 기관 : Sahmyook University

참고문헌

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피인용 문헌

  1. Prolidase-dependent mechanism of (Z)-8,9-epoxyheptadeca-1,11,14-triene-induced inhibition of collagen biosynthesis in cultured human skin fibroblasts vol.30, pp.6, 2012, https://doi.org/10.1080/14786419.2015.1038535
  2. Capillin protects against non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation and oxidative stress vol.43, pp.6, 2021, https://doi.org/10.1080/08923973.2021.1984520