Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Human Herpes Virus-8 Unrelated Primary Effusion Lymphoma-Like Lymphoma Presented as Pleural Effusion

  • Kim, Kyung Ho (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine) ;
  • Lee, Ji-Hyun (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine) ;
  • Jeong, Hye Cheol (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine) ;
  • Kim, Gun-Woo (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine) ;
  • Song, Sang Hee (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine) ;
  • Jung, So-Young (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine) ;
  • Kim, Gwang Il (Department of Pathology, CHA Bundang Medical Center, CHA University College of Medicine) ;
  • Kim, Eun Kyung (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine)
  • Received : 2012.05.21
  • Accepted : 2012.07.03
  • Published : 2012.12.30
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Abstract

Primary effusion lymphoma (PEL) is a rare type of lymphoma that arises in the body cavity without detectable masses. It is associated with human herpes virus-8 (HHV-8), Epstein-Barr virus (EBV), and human immunodeficiency virus (HIV). Recently, PEL unrelated to viral infection has been reported and it has been termed HHV-8 unrelated primary effusion lymphoma-like lymphoma (HHV-8 unrelated PEL-like lymphoma). Here, we report a case of HHV-8 unrelated PEL-like lymphoma in an 80-year-old woman. Chest X-ray and computed tomography revealed left-sided pleural effusion. Pleural effusion analysis and mediastinoscopic biopsy showed atypical cells that had originated from the B cells. The cells were positive for CD20 and bcl-2, but negative for CD3, CD5, CD21, CD30, CD138, epithelial membrane antigen, and HHV-8. Serological tests for HIV and EBV were negative. Considering the patient's age, further treatments were not performed. She has shown good prognosis without chemotherapy for more than 18 months.

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References

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