Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Typhlitis Developed after Chemotherapy with Irinotecan and Cisplatin in a Patient with Small Cell Lung Carcinoma

  • Ji, Eun Hye (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Young Min (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Soo Jeong (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Yeom, Soo Jeong (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Ha, Sung Eun (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kang, Hyeon Hui (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kang, Ji Young (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Lee, Sang Haak (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Moon, Hwa Sik (Department of Internal Medicine, The Catholic University of Korea College of Medicine)
  • Received : 2012.08.13
  • Accepted : 2012.10.23
  • Published : 2012.11.30
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Abstract

Typhlitis is a necrotizing colitis that usually occurs in neutropenic patients and develops most often in patients with hematologic malignancies such as leukemia and lymphoma. Typhlitis may proceed to bowel perforation, peritonitis and sepsis, which requires immediate treatment. Irinotecan is a semisynthetic analogue of the natural alkaloid camptothecin which prevents DNA from unwinding by inhibition of topoisomerase I. It is mainly used in colon cancer and small cell lung carcinoma (SCLC), of which the most common adverse effects are gastrointestinal toxicities. To the best of our knowledge, no case of typhlitis after chemotherapy with a standard dose of irinotecan in a solid tumor has been reported in the literature. We, herein, report the first case of typhlitis developed after chemotherapy combining irinotecan and cisplatin in a patient with SCLC.

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References

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  1. Cisplatin/irinotecan : Typhlitis in an elderly patient: case report vol.1438, pp.1, 2012, https://doi.org/10.1007/s40278-013-1245-8
  2. Spontaneous Intestinal Perforation: An Atypical Presentation of Neutropenic Enterocolitis—A Case Report vol.2014, pp.None, 2012, https://doi.org/10.1155/2014/925078
  3. Typhlitis (neutropenic enterocolitis) in patients with acute leukemia: a review vol.10, pp.2, 2012, https://doi.org/10.1080/17474086.2017.1280389
  4. Lesser Known Facts of Small Cell Lung Cancer : vol.43, pp.4, 2019, https://doi.org/10.1097/rct.0000000000000847