Advances in environmental research

  • 제1권2호
  • /
  • Pages.109-123
  • /
  • 2012
  • /
  • 2234-1722(pISSN)
  • /
  • 2234-1730(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

Effects of solanum macrocarpon (African eggplant) on haematological parameters of wistar rats exposed to urban air pollution

  • Olajire, A.A. (Industrial and Environmental Chemistry Unit, Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology) ;
  • Azeez, L. (Department of Chemical Sciences, Fountain University)
  • 투고 : 2012.05.02
  • 심사 : 2012.07.24
  • 발행 : 2012.06.25
⟨ 이전 논문 다음 논문 ⟩

초록

Our study investigated the effects of Solanum macrocarpon (African eggplant) on haematological and biochemical parameters of male albino rats exposed to urban air pollution ($O_3$, $PM_{10}$, CO, $SO_2$, $NO_2$ and VOC). Male albino Wistar rats were exposed for 63 days either to urban air pollution without treatment (A); oral supplementation with Solanum macrocarpon given at 36 and 75 mg/kg body weight (BW), representing C and D respectively and exposed to air pollution; oral supplementation with Solanum macrocarpon given at 75 mg/kg BW after exposure to air pollution (B); or kept in animal house without exposure to air pollution (E). Animals exposed to air pollution showed significant alterations in haematological and biochemical parameters signaling that the blood and organs were badly injured. There were significant elevations in white blood cells (WBC) and its indices, reduction in red blood cells (RBC) and significant depletions of non-enzymic antioxidants, total protein and increase in lipid peroxidation values. Solanum macrocarpon supplementation in the feed of animals halted significantly the deleterious effects of air pollution, with co-administration during exposure given better results.

키워드

참고문헌

  1. Abam, F.I. and Unachukwu, G.O. (2009), "Vehicular emission and air quality standards in Nigeria", Eur. J. Sci. Res., 34(4), 550-560.
  2. Agarwal, A. and Guleria, R. (2008), "Combined effects of $SO_2$ and $NO_2$ gas on blood features of albino rat", Electron. J. Environ. Sci., 1, 57-60.
  3. Ajayi, A.B. and Dosunmu, O.O. (2002), "Environmental hazards of importing used vehicles into Nigeria", Proceedings of International Symposium on Environmental Pollution Control and Waste Management, Tunis, Tunisia, January.
  4. Aljumaah, R.S and Hussein, M.F. (2011), "Haematological, hemostatic and blood chemical values of captive Erlanger's Gazelles (Gazella erlangeri) in Saudi Arabia", J. Anim. Veter. Adv., 10(13), 1699-1705. https://doi.org/10.3923/javaa.2011.1699.1705
  5. Amin, M.A., Amin, A.P. and Kulkarni, H.R. (2004), "Platelet distribution width (PDW) is increased in vaso-occlusive crisis in sickle cell disease", Ann. Hematol., 83(6), 331-335. https://doi.org/10.1007/s00277-003-0833-8
  6. Avogbe, P.H., Ayi-Fanou, L., Cachon, B., Chabi, N., Debende, A., Dewaele, D., Aissi, F., Cazier, F. and Sanni, A. (2011), "Hematological changes among Beninese motor-bike taxi drivers exposed to benzene by urban air pollution", Afr. J. Environ. Sci. Technol., 5(7), 464-472.
  7. Blum, A., Ommen, S.R., Thomson, S.P. and Gibbons, R.J. (1998), "Role of lymphocytes in heart disease: response", Circulation, 98, 1587-1590. https://doi.org/10.1161/01.CIR.98.15.1587
  8. Burton, G.W. and Traber, M.G. (1990), "Vitamin E: Antioxidant activity, biokinetics and bioavailability", Annu. Rev. Nutr., 10, 357-382. https://doi.org/10.1146/annurev.nu.10.070190.002041
  9. Chinedu, S.N., Olasumbo, A.C., Eboji, O.K., Emiloju, O.C., Arinola, O.K., and Dania, D.I. (2011), "Proximate and phytochemical analyses of Solanum aethiopicum L. and Solanum macrocarpon L. Fruits", Res. J. Chem. Sci., 1(3), 63-71.
  10. Cushnie, T.P.T. and Lamb, A.J. (2005), "Antimicrobial activity of flavonoids", Int. J. Antimicrob. Agents, 26(5), 343-356. https://doi.org/10.1016/j.ijantimicag.2005.09.002
  11. de Sossa, R.R., Queiroz, K.C., Souza, A.C., Gurgueira, S.A., Augusto, A.C., Miranda, M.A., Peppelenbosch, M.P., Ferreira, C.V. and Aoyama, H. (2007), "Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin", J. Enzym. Inhib. Med. Ch., 22(4), 439-444. https://doi.org/10.1080/14756360601162063
  12. Docci, D., Delvecchio, C., Gollini, C., Turci, F., Baldrati, L. and Gilli, P. (1989), "Red blood cell volume distribution width (RDW) in uraemic patients on chronic haemodialysis", Int. J. Artif. Ograns, 12(3), 170-174.
  13. Edewor, T.I., Olajire, A.A. and Olaniyan, L.E.B. (2007), "Effects of oral administration of ethanolic leaf extract of Acanthospermum hispidum DC on carbon tetrachloride induced acute liver injury in rats", Res. J. Med. Sci., 1(1), 39-41.
  14. Elsayed, N.M. (2001), "Antioxidant mobilization to oxidative stress: A dynamic environmental-nutrition interaction", Nutrition, 17(10), 828-834. https://doi.org/10.1016/S0899-9007(01)00646-3
  15. El-Gendy, K.S., Aly, N.M., Mahmoud, F.H., Kenawy, A. and El-Sebae, A.K.H. (2010), "The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid", Food Chem. Toxicol., 48(1), 215-221. https://doi.org/10.1016/j.fct.2009.10.003
  16. Enemeri, J.J. (2001), "Vehicular emission, environmental and health implications", Conference on Phase-out of leaded gasoline in Nigeria, Nigeria.
  17. Gornall, A.G. (1949), "Determination of serum protein by means of biuret reaction", J. Biol. Chem., 177, 751-766.
  18. Gorriz, A., Llacuna, S., Reira, M. and Nadal, J. (1996), "Effects of air pollution on haematological and plasma parameters in Apodemus sylvaticus and Mus musculus", Arch. Environ. Con. Tox., 31, 153-158. https://doi.org/10.1007/BF00203920
  19. Golalipour, M.J., Roshandel, D., Roshandel, G., Ghafari, S., Kalavi, M. and Kalavi, K. (2007), "Effect of lead intoxication and D-penicillamine treatment on hematological indices in rats", Int. J. Morphol., 25(4), 717-722.
  20. Gunawardena, H.P. and Silva, K.D.R. (2006), "Determination of total antioxidant capacity and vitamin C content of selected local underutilized and commonly consumed fresh fruits", 4th Food Nutr. Symposium, 4, 12-15.
  21. Henderson, L., Brusick, D., Ratpan, F. and Veenstra, G. (2007), "A review of the genotoxicity of ethylbenzene", Mutat. Res., 635(2-3), 81-89. https://doi.org/10.1016/j.mrrev.2007.03.001
  22. Hrelia, P., Maffei, F., Angelini, S. and Forti, G.C. (2004), "A molecular epidemiological approach to health risk assessment of urban air pollution", Toxicol. Lett., 149(1-3), 261-267. https://doi.org/10.1016/j.toxlet.2003.12.037
  23. Huang, S.H., Yu, C.W. and Lin, C.H. (2005), "Hydrogen peroxide functions as a stress signal in plants", Bot. Bull. Acad. Sinica., 46, 1-10.
  24. Jassim, H.M. and Hassan, A.A. (2011), "Changes in some blood parameters in lactating female rats and their pups exposed to lead: effects of vitamins C and E", Iraq. J. Veter. Sci., 25(1), 1-8.
  25. Kampa, M. and Castanas, E. (2008), "Human health effects of air pollution", Environ. Pollut., 151(2), 362-367. https://doi.org/10.1016/j.envpol.2007.06.012
  26. Karagoz, B., Alacacioolu, A., Bilgi, O., Demirci, H., Ozgun, A., Erikci, A.A., Sayan, O., Yilmaz, B. and Kandemir, E.G. (2009), "Platelet count and platelet distribution width increase in lung cancer patients", Anat. J. Clin. Invest., 3(1), 32-34.
  27. Laso, F.J., Mateos, F., Ramos, R., Herrero, F., Perez-Arellano, J.L. and Gonzalez-Buitrago, J.M. (1990), "Amplitude of the distribution of erythrocyte size in the differential diagnosis of microcytic anemia", Medicina Clin., 94(1), 1-4.
  28. Lee, C.R., Yoo, C.I., Lee, J.H., Kim, A.-R. and Kim, Y. (2002), "Hematological changes of children exposed to volatile organic compounds containing low levels of benzene", Sci. Tot. Environ., 299(1-3), 237-245. https://doi.org/10.1016/S0048-9697(02)00228-0
  29. Leong, S.T., Muttamara, S. and Laortanakul, P. (2002), "Air pollution and traffic measurements in Bangkok streets", Asian J. Ene. Environ., 3(3-4), 185-213.
  30. Lirong, Z., Xinming, W., Quisheng, H., Hao, W., Guoying, S., Chan, L.Y., Jiamo, F. and Blake, D.R. (2004), "Exposure to hazardous volatile organic compounds, $PM_{10}$ and CO while walking along streets in urban Guangzhou, China", Atmos. Environ., 38(37), 6177-6184. https://doi.org/10.1016/j.atmosenv.2004.07.025
  31. Liu, R.H. (2004), "Potential synergy of phytochemicals in cancer prevention: mechanism of action", Nutrition, 134(12), 3479-3485.
  32. Macchionea, M. and Garciab, M.L.B. (2011), Air pollution, oxidative stress and pulmonary defense, Karger, Basel, Switzerland.
  33. Mansour, S.A., Mossa, A.H. and Heikal, T.M. (2007), "Haematoxicity of a new natural insecticide "Spinosad" on male albino rats", Int. J. Agri. Bio., 9(2), 342-346.
  34. NIH (1985), Guide for the care and use of laboratory animals, NIH publication, 1985.
  35. Nikolic, M., Nikic, D. and Stankovic, A. (2008), "Effects of air pollution on red blood cells in children", Pol. J. Environ. Stud., 17(2), 267-271.
  36. Olajire, A.A. and Azeez, L. (2011), "Total antioxidant activity, phenolic, flavonoid and ascorbic acid contents of Nigerian vegetables", Afr. J. Food Sci. Technol., 2(2), 22-29.
  37. Olajire, A.A., Azeez, L. and Oluyemi, E.A. (2011), "Exposure to hazardous air pollutants along Oba Akran road, Lagos - Nigeria", Chemosphere, 84(8), 1044-1051. https://doi.org/10.1016/j.chemosphere.2011.04.074
  38. Oyarzun, M., Nelson Dussaubat, N. and Sergio Gonzalez, S. (2005), "Effect of 0.25 ppm ozone exposure on pulmonary damage induced by bleomycin", Biol. Res., 38, 353-358.
  39. Palozza, P., Lubertoc, S., Calviellog, S., Ricc, P. and Barfoli, G.M. (1997), "Antioxidant and prooxidant role of ${\beta}$-carotene in murine normal and tumor thymocytes: Effects of oxygen partial pressure", Free Radical Bio. Med., 22(6), 1065-1073. https://doi.org/10.1016/S0891-5849(96)00498-4
  40. Pari, L and Amali, D.R. (2005), "Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats", J. Physiol. Sci., 8(1), 115-123.
  41. Poursafa, P., Kelishadi, R., Amini, A., Amini, A., Amin, M.M., Lahijanzadeh, M. and Modaresi, M. (2011), "Association of air pollution and hematologic parameters in children and adolescents", J. Pediatr. (Rio J), 87(4), 350-356. https://doi.org/10.2223/JPED.2115
  42. Rom, W.N. (2011), "Role of oxidants in interstitial lung diseases: Pneumoconioses, constrictive bronchiolitis, and chronic tropical pulmonary eosinophilia", Mediat. Inflamm., 1-5.
  43. Romieu, I., Castro-Giner, F., Kunzli, N. and Sunyer, J. (2008), "Air pollution, oxidative stress and dietary supplementation: A review", Eur. Respir. J., 31(1), 179-197. https://doi.org/10.1183/09031936.00128106
  44. Sarada, S.K.S., Dipti, P., Anju, B., Pauline, T., Kain, A.K., Sairam, M., Sharma, S.K., Ilavazhagan, G., Kumar, D. and Selvamurthy, W. (2002), "Antioxidant effect of beta-carotene on hypoxia induced oxidative stress in male albino rats", J. Ethnopharmacol., 79(2), 149-153. https://doi.org/10.1016/S0378-8741(01)00360-9
  45. Saadat, M. and Bahaoddini, A. (2004), "Hematological changesdue to chronic exposure to natural gas leakage in polluted areas of Masjid-i-Sulaiman", Ecotox. Environ. Safe., 58(2), 273-276. https://doi.org/10.1016/j.ecoenv.2003.07.005
  46. Shrey, K., Suchit, A., Deepika, D., Shruti, K. and Vibha, R. (2011), "Air pollutants: The key stages in the pathway towards the development of cardiovascular disorders", Environ. Toxicol. Phar., 31(1), 1-9. https://doi.org/10.1016/j.etap.2010.09.002
  47. Simon-Schnass, I.M. (1992), "Nutrition at high altitude", Nutrition, 122(3), 778-781. https://doi.org/10.1093/jn/122.suppl_3.778
  48. Suzuki, J. and Katoh, N. (1990), "A simple and cheap method for measuring serum vitamin A in cattle using only spectrophotometer", Japan J. Veter. Sci., 52(6), 1282-1284.
  49. Syd Bom, A., Blomberg, S., Parnia, N., Stenfors, T. and Sand Strom, S. (2001), "Health effects of diesel exhaust emissions", Eur. Respir. J., 17(4), 733-737. https://doi.org/10.1183/09031936.01.17407330
  50. Tan, W.C., Qiu, D., Liam, B.I., Tze, P., Lee, N.S.H., Van Eeden, S.F., D'yachkova, Y. and Hogg, J.C. (2000), "The human bone marrow response to acute air pollution caused by forest fires", Am. J. Resp. Crit. Care, 161(4), 1213-1217. https://doi.org/10.1164/ajrccm.161.4.9904084
  51. Vagdatli, E., Gounari, E., Lazaridou, E., Katsibourlia, E., Tsikopoulou, F. and Labrianou, I. (2010), "Platelet distribution width: a simple, practical and specific marker of activation of coagulation", HIPPOKRATIA, 14(1), 28-32.
  52. WHO (1998), Basic OECD principles of GLP, Geneva, Switzerland.
  53. Yanga, W. and Omayeb, S.T. (2009), "Air pollutants, oxidative stress and human health", Mutat. Res.-Gen. Tox. En., 674(1-2), 45-54. https://doi.org/10.1016/j.mrgentox.2008.10.005
  54. Yakubu, M.T., Akanji, M.A. and Oladiji, A.T. (2005), "Aphrodisiac potentials of the aqueous extract of Fadogia argresits (Schweinf. Ex Hiern) stem in male albino rats", Asian J. Androl., 7(4), 399-404. https://doi.org/10.1111/j.1745-7262.2005.00052.x
  55. Yamamoto, Y. and Gaynor, R.B. (2001), "Therapeutic potential of inhibition of the NF-kB pathway in the treatment of inflammation and cancer", J. Clin. Invest., 107(2), 135-142. https://doi.org/10.1172/JCI11914
  56. Yilmaz, M.B., Saricam, E., Biyikoglu, S.F., Guray, Y., Guray, U., Sasmaz, H. and Korkmaz, S. (2004), "Mean platelet volume and exercise stress test", Thrombolysis, 17(2), 115-1120. https://doi.org/10.1023/B:THRO.0000037666.01018.8c
  57. Ziecha, D., Francob, R., Georgakilasc, A.G., Georgakilac, S., Malamou-Mitsid, V., Schonevelde, O., Pappaf, A. and Panayiotidisg, M.I. (2010), "The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development", Chem. Bio. Interact., 188(2), 334-339. https://doi.org/10.1016/j.cbi.2010.07.010

피인용 문헌

  1. An Efficient Removal of Disperse Dye from Wastewater Using Zeolite Synthesized from Cenospheres vol.21, pp.4, 2017, https://doi.org/10.1061/(ASCE)HZ.2153-5515.0000369
  2. Electrochemical detection of 4-nitrophenol based on biomass derived activated carbons vol.6, pp.14, 2014, https://doi.org/10.1039/c4ay00795f
  3. Properties of concrete modified with waste Low Density Polyethylene and saw dust ash vol.80, 2017, https://doi.org/10.1088/1755-1315/80/1/012020
  4. Potassium hydroxide activation of activated carbon: a commentary vol.16, pp.4, 2015, https://doi.org/10.5714/CL.2015.16.4.275
  5. Prostate Specific Antigen, Antioxidant and Hematological Parameters in Prostatic Rats Fed Solanum macrocarpon L. Leaves vol.8, pp.1, 2015, https://doi.org/10.3923/ajbs.2015.30.41
  6. Identification of Key Indicators for Sustainable Construction Materials vol.2018, pp.1687-8442, 2018, https://doi.org/10.1155/2018/6916258
  7. pp.1369-1619, 2020, https://doi.org/10.1080/09603123.2019.1577367
  8. Functional porous carbon–ZnO nanocomposites for high-performance biosensors and energy storage applications vol.18, pp.24, 2016, https://doi.org/10.1039/c6cp01285j
  9. Efficient [FORMULA OMISSION] adsorption using peach stone-derived granular activated carbon vol.9, pp.None, 2012, https://doi.org/10.1038/s41598-019-39964-y
  10. Strength characterization of novel concrete using plastic waste as additional material vol.872, pp.None, 2012, https://doi.org/10.1088/1757-899x/872/1/012178