Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Regular Exercise and L-Arginine Intake on Abdominal Fat, GH/IGF-1 Axis, and Circulating Inflammatory Markers in the High Fat Diet-Induced Obese Aged Rat

규칙적인 운동과 L-arginine의 섭취가 고지방식이 유도 비만 노화생쥐의 복부지방량, GH/IGF-1 axis 및 혈관염증지표에 미치는 영향

  • Park, Sok (Division of Sports industry & Science, Mokwon University) ;
  • Sung, Ki-Woon (Department of Physical education, Sejong University) ;
  • Lee, Jin (Department of Anatomy and Cell Biology, Collage of Medicine, Hanyang University) ;
  • Lee, Cheon-Ho (Department of Physical education, Continuing Education Center, Konkuk University) ;
  • Lee, Young-Jun (Department of Sports for All, Collage of Humanities, Soongsil University) ;
  • Yoo, Young-June (Department of modeling, Collage of Performance Arts, Dongduk Women's University) ;
  • Park, Kyoung-Shil (DMajor of Leisure & Sport Studies, College of Physical Sciences, Kyonggi University) ;
  • Min, Byung-Jin (DMajor of Leisure & Sport Studies, College of Physical Sciences, Kyonggi University) ;
  • Shin, Yong-Sub (Department of Combative Martial Arts Training, College of Martial Arts, Yongin University) ;
  • Kim, Jung-Suk (Department of Judo, College of Martial Arts, Yongin University) ;
  • Jung, Hun (Department of Judo, College of Martial Arts, Yongin University)
  • 박석 (목원대학교 스포츠산업학부) ;
  • 성기운 (세종대학교 체육학과) ;
  • 이진 (한양대학교 의과대학 해부세포생물학교실) ;
  • 이천호 (건국대학교 미래지식교육원) ;
  • 이영준 (숭실대학교 체육학과) ;
  • 유영준 (동덕여자대학교 모델학과) ;
  • 박경실 (경기대학교 레저.건강학과) ;
  • 민병진 (경기대학교 레저.건강학과) ;
  • 신용업 (용인대 학교 격기지도학과) ;
  • 김정석 (용인대학교 유도학과) ;
  • 정훈 (용인대학교 유도학과)
  • Received : 2012.01.05
  • Accepted : 2012.04.04
  • Published : 2012.04.30
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Abstract

The purpose of this study was to investigate the effect of exercise and/or L-arginine on abdominal fat, IGF-1 on GH/IGF-1 axis, fibrinogen, and PAI-1 in aged and obese rats. Male Sprague-Dawley rats were treated with a D-galactose aging inducing agent (50 mg/kg) given intraperitoneally for 12 weeks. Thirty-two male Sprague-Dawley rats were treated and divided into four groups: aging-high fat diet group (AG+HF), AG+HF with L-arginine intake group (AG+LA), AG+HF with exercise group (AG+EX), and AG+EX with L-arginine intake group (AG+LA+EX). The experimental rats underwent treadmill training (60 min/day, 6 days/week at 0% gradient) for 12 weeks. L-arginine was given orally (150 mg/kg/day) for 12 weeks. After the experiment, blood was collected from the left ventricle and abdominal fat was extracted. The results showed that GH was significantly increased in AG+EX and AG+AL+EX. IGF-1 was significantly increased in both the AG+AL+EX and AG+EX group ($p$<0.05), while fibrinogen and PAI-1 were not significantly different among the groups. Abdominal fat was significantly decreased in the AG+LA, AG+EX, and AG+LA+EX groups ($p$<0.05) compared with the AG+HF group. In conclusion, this study suggests that exercise alone or L-arginine alone or a combination not only increases the GH and IGF-1 concentration, but also decreases the abdominal fat mass.

본 연구는 비만과 노화가 동시에 유발된 흰쥐에서 12주간의 트레드밀 운동과 L-arginine의 투여가 복부지방량, GH, IGF-I, somatostatin, fibrinogen, PAI-1에 미치는 영향을 관찰하고 이를 개선하는데 더욱 효과적인 방법을 제시하는데 그 목적이 있다. 이를 위해 단독 처치 군과 복합 처치 군으로 나누어 실험하여 그 효과를 비교, 분석한 결과 다음과 같은 결론을 얻었다. 1. 복부지방량은 통제집단에 비해 모든 집단에서 유의하게 감소하였다($p$<0.01). 2. AG+EX, AG+LA+EX집단에서 통제집단에 비해 GH의 혈중 농도가 유의하게 높게 나타났다($p$<0.1). 3. AG+EX, AG+LA+EX집단에서 통제집단에 비해 IGF-I의 혈중 농도가 유의하게 증가하였다($p$<0.01).

Keywords

References

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