Journal of Preventive Medicine and Public Health

  • 제45권2호
  • /
  • Pages.98-104
  • /
  • 2012
  • /
  • 1975-8375(pISSN)
  • /
  • 2233-4521(eISSN)
대한예방의학회 (The Korean Society for Preventive Medicine)
권호 표지
DOI QR코드

DOI QR Code

The Association Between Serum Albumin Levels and Metabolic Syndrome in a Rural Population of Korea

  • Cho, Hye-Min (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Kim, Hyeon-Chang (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Lee, Ju-Mi (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Oh, Sun-Min (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Choi, Dong-Phil (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Suh, Il (Department of Preventive Medicine, Yonsei University College of Medicine)
  • 투고 : 2011.08.03
  • 심사 : 2011.12.12
  • 발행 : 2012.03.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: A positive association between serum albumin levels and metabolic syndrome has been reported in observation studies, but it has not been established in the Korean population. The purpose of this study was to evaluate the association between serum albumin levels and the presence of metabolic syndrome among a sample of apparently healthy Korean adults. Methods: This cross-sectional study analyzed data of 3189 community-dwelling people (1189 men and 2000 women) who were aged 40 to 87 years and were living in a rural area in Korea. Serum albumin levels were classified into quartile groups for each sex. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines with an adjusted waist circumference cut-off value ${\geq}90\;cm$ for men and${\geq}85\;cm$ for women). An independent association between serum albumin levels and metabolic syndrome was assessed by multiple logistic regression analysis. Results: Higher serum albumin levels were associated with increased prevalence of metabolic syndrome. The odds ratio (95% confidence interval) of the prevalence of metabolic syndrome for the highest versus the lowest serum albumin quartiles was 2.81 (1.91 to 4.14) in men and 1.96 (1.52 to 2.52) in women, after adjusting for age, smoking status, alcohol consumption, and physical activity. When each metabolic abnormality was analyzed separately, higher serum albumin levels were significantly associated with hypertriglyceridemia and hyperglycemia in both sexes, and with abdominal obesity in men. Conclusions: These results suggest that higher serum albumin levels are positively associated with an increased risk of metabolic syndrome in Korean adults.

키워드

참고문헌

  1. Harris D, Haboubi N. Malnutrition screening in the elderly population. J R Soc Med 2005;98(9):411-414.
  2. Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett 2008;582(13):1783-1787.
  3. Arroyo V. Human serum albumin: not just a plasma volume expander. Hepatology 2009;50(2):355-357.
  4. Phillips A, Shaper AG, Whincup PH. Association between serum albumin and mortality from cardiovascular disease, cancer, and other causes. Lancet 1989;2(8677):1434-1436.
  5. Gillum RF, Makuc DM. Serum albumin, coronary heart disease, and death. Am Heart J 1992;123(2):507-513.
  6. Djousse L, Rothman KJ, Cupples LA, Levy D, Ellison RC. Serum albumin and risk of myocardial infarction and allcause mortality in the Framingham Offspring Study. Circulation 2002;106(23):2919-2924.
  7. Djousse L, Rothman KJ, Cupples LA, Arnett DK, Ellison RC; NHLBI Family Heart Study. Relation between serum albumin and carotid atherosclerosis: the NHLBI Family Heart Study. Stroke 2003;34(1):53-57.
  8. Folsom AR, Ma J, Eckfeldt JH, Nieto FJ, Metcalf PA, Barnes RW. Low serum albumin. Association with diabetes mellitus and other cardiovascular risk factors but not with prevalent cardiovascular disease or carotid artery intimamedia thickness. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Ann Epidemiol 1995;5(3):186-191.
  9. Nelson JJ, Liao D, Sharrett AR, Folsom AR, Chambless LE, Shahar E, et al. Serum albumin level as a predictor of incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol 2000;151(5):468-477.
  10. Danesh J, Muir J, Wong YK, Ward M, Gallimore JR, Pepys MB. Risk factors for coronary heart disease and acute-phase proteins. A population-based study. Eur Heart J 1999;20(13):954-959.
  11. Ishizaka N, Ishizaka Y, Nagai R, Toda E, Hashimoto H, Yamakado M. Association between serum albumin, carotid atherosclerosis, and metabolic syndrome in Japanese individuals. Atherosclerosis 2007;193(2):373-379.
  12. Kadono M, Hasegawa G, Shigeta M, Nakazawa A, Ueda M, Yamazaki M, et al. Serum albumin levels predict vascular dysfunction with paradoxical pathogenesis in healthy individuals. Atherosclerosis 2010;209(1):266-270.
  13. Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care 2005;28(7):1769-1778.
  14. Galassi A, Reynolds K, He J. Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med 2006;119(10):812-819.
  15. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502.
  16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28(7):412-419.
  17. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112(17):2735-2752.
  18. Lee SY, Park HS, Kim DJ, Han JH, Kim SM, Cho GJ, et al. Appropriate waist circumference cutoff points for central obesity in Korean adults. Diabetes Res Clin Pract 2007;75(1):72-80.
  19. Lemieux S, Prud'homme D, Bouchard C, Tremblay A, Despres JP. Sex differences in the relation of visceral adipose tissue accumulation to total body fatness. Am J Clin Nutr 1993;58(4):463-467.
  20. Pouliot MC, Despres JP, Lemieux S, Moorjani S, Bouchard C, Tremblay A, et al. Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol 1994;73(7):460-468.
  21. Kuk JL, Lee S, Heymsfield SB, Ross R. Waist circumference and abdominal adipose tissue distribution: influence of age and sex. Am J Clin Nutr 2005;81(6):1330-1334.
  22. Lovejoy JC, Sainsbury A; Stock Conference 2008 Working Group. Sex differences in obesity and the regulation of energy homeostasis. Obes Rev 2009;10(2):154-167.
  23. Jefferson DM, Reid LM, Giambrone MA, Shafritz DA, Zern MA. Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes. Hepatology 1985;5(1):14-20.
  24. Baker ME. Albumin, steroid hormones and the origin of vertebrates. J Endocrinol 2002;175(1):121-127.
  25. Kaysen GA, Stevenson FT, Depner TA. Determinants of albumin concentration in hemodialysis patients. Am J Kidney Dis 1997;29(5):658-668.
  26. Yeun JY, Kaysen GA. Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis patients. Am J Kidney Dis 1997;30(6):923-927.
  27. MacLennan WJ, Martin P, Mason BJ. Protein intake and serum albumin levels in the elderly. Gerontology 1977;23(5):360-367.
  28. Kelman L, Saunders SJ, Frith L, Wicht S, Corrigal A. Effects of dietary protein restriction on albumin synthesis, albumin catabolism, and the plasma aminogram. Am J Clin Nutr 1972;25(11):1174-1178.
  29. Thalacker-Mercer AE, Campbell WW. Dietary protein intake affects albumin fractional synthesis rate in younger and older adults equally. Nutr Rev 2008;66(2):91-95.
  30. Linn T, Santosa B, Gronemeyer D, Aygen S, Scholz N, Busch M, et al. Effect of long-term dietary protein intake on glucose metabolism in humans. Diabetologia 2000;43(10):1257-1265.
  31. Wolever TM, Hamad S, Gittelsohn J, Gao J, Hanley AJ, Harris SB, et al. Low dietary fiber and high protein intakes associated with newly diagnosed diabetes in a remote aboriginal community. Am J Clin Nutr 1997;66(6):1470-1474.
  32. Wang ET, de Koning L, Kanaya AM. Higher protein intake is associated with diabetes risk in South Asian Indians: the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study. J Am Coll Nutr 2010;29(2):130-135.

피인용 문헌

  1. Serum Albumin Levels: A Simple Answer to a Complex Problem? Are We on the Right Track of Assessing Metabolic Syndrome? vol.28, pp.1, 2012, https://doi.org/10.3803/enm.2013.28.1.17
  2. Association between Serum 25-Hydroxyvitamin D Level and Insulin Resistance in a Rural Population vol.55, pp.4, 2012, https://doi.org/10.3349/ymj.2014.55.4.1036
  3. Serum albumin concentration and incident type 2 diabetes risk: new findings from a population-based cohort study vol.58, pp.5, 2012, https://doi.org/10.1007/s00125-015-3520-0
  4. Increase in serum albumin concentration is associated with prediabetes development and progression to overt diabetes independently of metabolic syndrome vol.12, pp.4, 2012, https://doi.org/10.1371/journal.pone.0176209
  5. A comparative research on obesity hypertension by the comparisons and associations between waist circumference, body mass index with systolic and diastolic blood pressure, and the clinical laboratory vol.40, pp.1, 2012, https://doi.org/10.1080/10641963.2017.1281940
  6. Age-differential association between serum uric acid and incident hypertension vol.42, pp.3, 2019, https://doi.org/10.1038/s41440-018-0168-4
  7. Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study vol.20, pp.1, 2012, https://doi.org/10.1186/s12882-019-1220-6
  8. Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants vol.54, pp.5, 2012, https://doi.org/10.1080/14017431.2020.1762918
  9. The clinical role of serum albumin in Organophospate poisoning vol.128, pp.4, 2021, https://doi.org/10.1111/bcpt.13546