Effect of Hydrocortisone Aceponate - Gentamicin - Miconazole Topical Otic Combination for Treating Canine Otitis Externa

개 외이염 치료에서 하이드로코티손 아세포네이트-겐타마이신-미코나졸 국소 혼합제제의 효과

  • Park, Seol-Hee (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Lee, Yong-Uk (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Nam, Eui-Hwa (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Yi, Hak-Jin (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Jung, Ji-Young (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Han, Seung-Hee (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Song, Chi-Youn (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Hwang, Cheol-Yong (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
  • 박설희 (서울대학교 수의과대학.수의과학연구소) ;
  • 이용욱 (서울대학교 수의과대학.수의과학연구소) ;
  • 남의화 (서울대학교 수의과대학.수의과학연구소) ;
  • 이학진 (서울대학교 수의과대학.수의과학연구소) ;
  • 정지영 (서울대학교 수의과대학.수의과학연구소) ;
  • 한승희 (서울대학교 수의과대학.수의과학연구소) ;
  • 송치윤 (서울대학교 수의과대학.수의과학연구소) ;
  • 황철용 (서울대학교 수의과대학.수의과학연구소)
  • Accepted : 2012.02.14
  • Published : 2012.02.29

Abstract

Fifty-four dogs with otitis externa were enrolled in the study for the Evaluation of efficacy of a Hydrocortisone aceponate - Gentamicin - Miconazole otic combination ($Easotic^{(R)}$, Virbac, Carros, France). Otitis externa patients were treated by $Easotic^{(R)}$ once daily for 5 days and 2 days off treatment and evaluated on $7^{th}$ day. If otitis externa persisted, additional $Easotic^{(R)}$ treatment was administered once daily for 5 days and rested 2 days and reevaluated on $14^{th}$ day. For the evaluation of efficacy of $Easotic^{(R)}$, eight clinical signs were scored on a severity scale and infectious agents from ear sample were also graded using semi-quantitative scale at each visit. Sum of clinical scores and cytological scores was defined as Global Clinical Score. When $Easotic^{(R)}$ was applied once daily for 5 days, global clinical score was reduced 76.0%. When $Easotic^{(R)}$ was administered for 10 days, during first 5 days administration, 46.6% reduction of global clinical score was detected. During additional 5 days administration, 82.2% reduction of global clinical score was observed compared with Day 0. Any relevant adverse effect was not reported during the study in all cases. Thus, $Easotic^{(R)}$ treatment once daily for 5 days and 10 days appears to be effective and safe treatment for canine otitis externa.

54 마리의 외이염에 이환된 개에서 하이드로코티손 아세포네이트-겐타마이신-미코나졸 국소 혼합제제인 이소틱($Easotic^{(R)}$, Virbac, Carros, France)의 효과를 평가하였다. 외이염 환자들은 이소틱을 하루 1번 적용하여 5일 동안 치료 받았고 2일 동안 휴약 하였으며 처음 적용일로부터 7일 후 평가되었다. 적용 후에 외이염이 지속되는 경우 추가적으로 이소틱을 하루 1번 5일 동안 사용하고 2일 휴약 후에 처음 적용일로부터 14일 후 평가되었다. 이소틱의 효과를 평가하기 위해 8항목의 임상증상을 증상의 심한 정도로 등급을 매겨 점수화하였고 귀의 도말 표본에서 감염인자들을 준정량적으로 등급을 매겨 점수화하였다. 임상증상점수와 감염인자점수의 합을 전체임상점수로 정의하였다. 이소틱을 5일 동안 적용하였을 때 전체임상점수는 76% 감소하였다. 이소틱을 10일 동안 적용하였을 때 처음 5일 동안 전체임상점수는 46.6% 감소하였다. 추가적인 5일간 적용 후 처음 적용할 때와 비교하여 전체임상점수는 82.2% 감소하였다. 모든 케이스에서 실험 기간 동안 치료제와 관련된 부작용은 나타나지 않았다. 따라서 5일 간 이소틱 치료 및 10일 간 이소틱 치료는 개의 외이염을 치료하는데 있어서 효과적이고 안전한 방법으로 생각된다.

Keywords

References

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