Journal of Microbiology and Biotechnology

  • 제22권11호
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  • Pages.1482-1485
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  • 2012
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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An Antitumor Component from Fomitiporia ellipsoidea

  • Zan, Lifeng (Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University) ;
  • Bao, Haiying (Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University) ;
  • Bau, Tolgor (Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University) ;
  • Liu, Hanbin (Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University) ;
  • Cui, Baokai (Institute of Microbiology, Beijing Forestry University)
  • 투고 : 2012.06.04
  • 심사 : 2012.07.07
  • 발행 : 2012.11.28
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초록

A natural furan derivative was isolated from the methanolic extract of the fruit bodies of Fomitiporia ellipsoidea. Its chemical structure was elucidated as methyl 3,5-dioxo-1,3,5,7-tetrahydrobenzo[1,2-c:4,5-c']difuran-4-carboxylate by means of extensive NMR and MS data analysis, and named as fomitiporiaester A (1). Compound 1 showed significant antitumor activity to hepatoma $H_{22}$ in vivo, and the inhibition rates were 42.94%, 49.17%, and 58.15% at concentrations of 5, 10, and 20 mg/kg, respectively. Compound 1 showed weak cytotoxic activities against the human hepatoblastoma (HepG-2) and human oophoroma (Skov 3) cell lines with$IC_{50}$ values of more than $100{\mu}M$.

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참고문헌

  1. Cui, B. K. and Y. C. Dai. 2008. A new species of Fomitiporia (Basidiomycota) from Wanmulin Nature Reserve, Fujian Province. Mycotaxon 105: 343-348.
  2. Dai, Y. C. and B. K. Cui. 2011. Fomitiporia ellipsoidea has the largest fruiting body among the fungi. Fungal Biol. 115: 1-2. https://doi.org/10.1016/j.funbio.2010.09.012
  3. Ding, Y., H. Y. Bao, T. Bau, Y. Li, and Y. H. Kim. 2009. Antitumor components from Naematoloma fasciculare. J. Microbiol. Biotechnol. 19: 1135-1138.
  4. Lee, I. K. and B. S. Yun. 2011. Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. J. Antibiot. 64: 349-359. https://doi.org/10.1038/ja.2011.2
  5. Liu, H. B., H. Y. Bao, and B. K. Cui. 2011. Chemical constituents of Fomitiporia ellipsoidea fruiting bodies. Mycosystema 30: 459-463.
  6. Mascarenhas, M. 1994. Structure-activity characterization, a quick method to screen mushrooms for the presence of antitumor glucans. Mushroom Res. 3: 77-80.
  7. Zan, L. F., J. C. Qin, Y. M. Zhang, Y. H. Yao, H. Y. Bao, and X. Li. 2011. Antioxidant hispidin derivatives from medicinal mushroom Inonotus hispidus. Chem. Pharm. Bull .59: 770-772. https://doi.org/10.1248/cpb.59.770
  8. Zhou, Z. Y. and J. K. Liu 2010. Pigments of fungi (macromycetes). Nat. Prod. Rep. 27: 1531-1570. https://doi.org/10.1039/c004593d
  9. Zom, E., E. A. Nelson, and M. Mohseni. 2006. IL-2 regulates FOXP3expression in human $CD4^+CD25^+$ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 108: 1571-1579. https://doi.org/10.1182/blood-2006-02-004747

피인용 문헌

  1. A New Antioxidant Pyrano[4,3-c][2]benzopyran-1,6-dione Derivative from the Medicinal Mushroom Fomitiporia ellipsoidea vol.10, pp.2, 2012, https://doi.org/10.1177/1934578x1501000226
  2. Two new species of Fomitiporia (Hymenochaetales, Basidiomycota) from Tibet, southwest China vol.108, pp.5, 2012, https://doi.org/10.3852/16-011