Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Preparation of Poloxamer-based Hydrogels Using Electron Beam and Their Evaluation for Buccal Mucoadhesive Drug Delivery

전자빔을 이용한 폴록사머 하이드로젤의 제조 및 구강 점막부착성 약물전달을 위한 특성 분석

  • Baek, Eun-Jung (Department of Polymer Science and Engineering, Chungnam National University) ;
  • Shin, Baek-Ki (College of Pharmacy, Chungnam National University) ;
  • Nho, Young-Chang (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Lim, Youn-Mook (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Jong-Seok (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Jeong-Sook (College of Pharmacy, Chungnam National University) ;
  • Huh, Kang-Moo (Department of Polymer Science and Engineering, Chungnam National University)
  • 백은정 (충남대학교 고분자공학과) ;
  • 신백기 (충남대학교 약학대학) ;
  • 노영창 (한국원자력연구원 정읍방사선과학연구소 방사선공업환경연구부) ;
  • 임윤묵 (한국원자력연구원 정읍방사선과학연구소 방사선공업환경연구부) ;
  • 박종석 (한국원자력연구원 정읍방사선과학연구소 방사선공업환경연구부) ;
  • 박정숙 (충남대학교 약학대학) ;
  • 허강무 (충남대학교 고분자공학과)
  • Received : 2011.07.08
  • Accepted : 2011.08.11
  • Published : 2012.03.25
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Abstract

In this study, poloxamer hydrogels were prepared by electron beam irradiation and evaluated for potential application as a buccal mucoadhesive drug delivery system. Poloxamer, one of typical thermoresponsive polymers, was modified to have vinyl end groups for crosslinking reaction, and its hydrogels were fabricated by irradiation crosslinking reaction. Carbopol as a mucoadhesive polymeric additive was introduced to improve the mucoadhesive property of the hydrogels and its effect on the mucoadhesion and drug release properties was investigated. The results showed that the end group modification of poloxamer and the addition of carbopol improved mucoadhesive force and mechanical properties and led to a sustained drug release behavior.

본 연구에서는 전자빔을 이용하여 폴록사머 하이드로젤을 제조하여 구강 점막부착성 약물전달체로서의 특성을 평가하고자 하였다. 온도감응성을 나타내는 폴록사머 고분자의 말단에 가교반응을 위한 비닐기를 도입한 후, 방사선 가교반응을 이용하여 하이드로젤을 제조하였다. 점착성 향상을 위한 첨가제로 점착성 고분자인 카보폴을 첨가하여 하이드로젤을 제조하였고, 카보폴이 점막부착성과 서방성 방출에 미치는 영향을 알아보았다. 결과적으로, 폴록사머 고분자의 말단 개질과 카보폴의 첨가에 의해 하이드로젤의 기계적 물성과 점막부착성이 향상되었고, 약물방출실험 결과 약물이 방출되는 속도가 지연되는 결과를 확인하였다.

Keywords

Acknowledgement

Supported by : 한국연구재단

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