Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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Restoration of Calvarial Defect Using a Variety of Xenogenous Tooth Bone Graft Material: Animal Study

다양한 이종치아 골이식재를 이용한 두개골 결손부 수복: 동물 연구

  • Kim, Young-Kyun (Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National Univerity Bundang Hospital) ;
  • Kim, Jong-Hwa (Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National Univerity Bundang Hospital) ;
  • Hwang, Ji-Yeon (Preclinical Research Center, Biomedical Research Institute, Seoul National Univerity Bundang Hospital) ;
  • Um, In-Woong (Korea Tooth Bank, R&D Institute) ;
  • Jeong, Dongjun (Department of Pathology, College of Medicine, Soon Chun Hyang University) ;
  • Yun, Pil-Young (Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National Univerity Bundang Hospital)
  • 김영균 (분당서울대학교병원 치과 구강악안면외과) ;
  • 김종화 (분당서울대학교병원 치과 구강악안면외과) ;
  • 황지연 (분당서울대학교병원 의생명연구원 전임상실험센터) ;
  • 엄인웅 (한국치아은행 연구개발기관) ;
  • 정동준 (순천향대학교 의과대학 병리학교실) ;
  • 윤필영 (분당서울대학교병원 치과 구강악안면외과)
  • Received : 2012.07.17
  • Accepted : 2012.08.27
  • Published : 2012.09.30
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Abstract

Purpose: The purpose of this study was to evaluate the histological healing process of 3 different types of xenogenic tooth bone graft material and xenogenic bone graft material. Methods: Three types of human tooth bone graft material (chips, crowns, and roots) and BioOss (Geistlich Pharma AG, Wolhausen, Switzerland) was filled at the preformed 4 round-shaped calvarial bone defects of beagle dogs. The beagles were sacrificed at 2, 4, 8, and 12 weeks, respectively, for radiological and histological evaluation. Results: Increased strength and radiopacity were detected in all graft material groups in time-dependent manner. New bone was formed and matured surrounding the graft material histologically. Also, a new bone was directly integrated with graft material. Conclusion: It was expected that newly developed tooth bone graft material would show good bone healing capacity if it was used as a graft material for the restoration of bony defect.

Keywords

References

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