Asian Pacific Journal of Cancer Prevention

  • 제13권12호
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  • Pages.6077-6081
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Pretreatment Thrombocytosis as a Prognostic Factor in Women with Gynecologic Malignancies: a Meta-analysis

  • Yu, Min (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
  • Liu, Lei (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
  • Zhang, Bing-Lan (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
  • Chen, Qi (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
  • Ma, Xue-Lei (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
  • Wu, Yu-Ke (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
  • Liang, Chun-Shui (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
  • Niu, Zhi-Min (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
  • Qin, Xin (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
  • Niu, Ting (Department of Hematology, West China Hospital, Sichuan University)
  • 발행 : 2012.12.31
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초록

Background: This study was performed to analyze the prognostic implications of pretreatment or preoperative thrombocytosis in women with gynecologic malignancies. Material and Methods: We surveyed 2 medical databases, PubMed and EMBASE, to identified all relevant studies. A total of 14 (n=3,490) that evaluated the link between thrombocytosis and 5-year survival were included. REVMAN version 5.1 was used for our analysis and publication bias was evaluated using the Begg's funnel plot and tested by STATA 11.0. Risk ratios (RRs) with 95% confidence intervals (CIs) generated by the random effect model were used to assess the strength of any association. Results: 709(20.3%) of the 3,490 patients exhibited thrombocytosis (platelet counts > $400{\times}10^9/L$) at primary diagnosis, and their mortality was 1.62-fold higher compared with the others (RR=1.62, 95%CI=[1.28-2.05], p<0.0001). Thrombocytosis failed to have a stronger effect on the survival of advanced patients of stages III to IV in our study (n=478, RR=1.29, 95% CI=[1.13-1.48], p=0.0003), nor in women with cervical cancer in stage IB (n=1371, RR=1.73, 95% CI=[1.71-2.58], p=0.007). In addition, when adjusted for different carcinoma, it was associated with worse prognosis for all except the ones with vulvar cancer (n=201, RR=0.43, 95% CI=[0.14-1.29], p=0.13). Conclusions: This meta-analysis indicated that thrombocytosis might be associated with a worse prognosis for patients with gynecologic malignancies but without specificity or sensitivity for the ones in advanced stage. When adjusted for different gynecologic malignancies, it showed a significant effect on survival of all except vulvar cancers.

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  2. Thresholds and timing of pre-operative thrombocytosis and ovarian cancer survival: analysis of laboratory measures from electronic medical records vol.16, pp.1, 2016, https://doi.org/10.1186/s12885-016-2660-z
  3. Pretreatment thrombocytosis as a significant prognostic factor in malignant mesothelioma: a meta-analysis vol.28, pp.6, 2017, https://doi.org/10.1080/09537104.2016.1246712
  4. The clinicopathological and prognostic role of thrombocytosis in patients with cancer: A meta-analysis vol.13, pp.6, 2017, https://doi.org/10.3892/ol.2017.6054
  5. The prognostic role of pretreatment platelet-to-lymphocyte ratio as predictors in patients with colorectal cancer: a meta-analysis vol.11, pp.1, 2017, https://doi.org/10.2217/bmm-2016-0181
  6. The pretreatment thrombocytosis may predict prognosis of patients with colorectal cancer: a systematic review and meta-analysis vol.11, pp.2, 2017, https://doi.org/10.2217/bmm-2016-0214