Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Lack of Association between Herpes Simplex Virus Type 2 Infection and Cervical Cancer - Taq Man Realtime PCR Assay Findings

  • Farivar, Taghi Naserpour (Cell and Molecular Research Center, Qazvin University of Medical Sciences) ;
  • Johari, Pouran (Cell and Molecular Research Center, Qazvin University of Medical Sciences) ;
  • Shafei, Shilan (Cell and Molecular Research Center, Qazvin University of Medical Sciences) ;
  • Najafipour, Reza (Cell and Molecular Research Center, Qazvin University of Medical Sciences) ;
  • Reza, Najafipour (Cell and Molecular Research Center, Qazvin University of Medical Sciences)
  • Published : 2012.01.31
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Abstract

Background: About one third of the human population suffer cancer during their lifetime and more than 20% of total morbidity is related to neoplasia. Cervical cancer is generally the most common cancer in developing countries and the second most common in women globally. The role of human papilloma viruses viruses in its induction is clear. However, the involvement of hepres simplex virus type 2 (HSV-2) is controversial. Therefore a survey was conducted of the prevalence of HSV-2 in patients with cervical cancer and also healthy people with sensitive and quantitative Taq Man real-time PCR assay. Materials and methods: Seventy six formaldehyde fixed paraffin embedded tissue specimens from patients with histologically proven history of cervical cancer as well as 150 control blocks were sectioned for deparaffinization and DNA extraction. Results: There was no HSV-2 DNA in our patient specimens but four control samples were positive, all with a history of hysterectomy. Conclusion: Considering the absence of any positive viral HSV-2 DNA in our patients and also the presence of four positive specimens among our controls, we did not find any relationship between the presence of HSV-2 DNA and cervical cancer.

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References

  1. Anonymous (2006). Announcement the society of Gynecologic oncologists' statement on a cervix cancer vaccine. Gynecol Oncol, 10, 377.
  2. Brady R, Bernstein D (2004). Treatment of herpes simplex infection. Antiviral Res, 61, 73-81. https://doi.org/10.1016/j.antiviral.2003.09.006
  3. Di Paolo J, Woodworth CD, Coutlee F, et al (1998). Relationship of stable integration of herpes simplex virus 2 Bgl II N sub-fragment Xho-2 to malignant transformation of human Papilloma virus - immortalized cervical kerationcytes. Int J Cancer, 76, 865-71. https://doi.org/10.1002/(SICI)1097-0215(19980610)76:6<865::AID-IJC16>3.0.CO;2-1
  4. Disease Control and Prevention, and National Cancer Institute; 2010. Available at: http://www.cdc.gov/uscs
  5. Hoenil J, Weon K (2005). Implications of HPV infection in uterine cervical cancer. Cancer Therapy, 3, 419-34.
  6. Jalouli J, Ibrahim SO, Mehrotra R, et al (2010). Prevalence of viral (HPV, EBV, HSV) infections in oral submucous fibrosis and oral cancer from India. Acta Otolaryngol, 130, 1306-11 https://doi.org/10.3109/00016481003782041
  7. Jones C,(1995).Cervical cancer: is herpes simplex virus type II a cofactor? Clin Microbiol Rev, 8, 549-56.
  8. Kanerva A, Lavilla-Alonso S, Raki M (2008). Systemic therapy for cervical cancer with potentially regulatable oncolytic adenoviruses. PLoS, 3, e2917 https://doi.org/10.1371/journal.pone.0002917
  9. Kjaer SK, Villiers E, Haugaard BJ, et al (2006). Human papillomavirus, herpes simplex virus & cervical cancer incidence in Greenland & Denmark. Int J Cancer, 41, 518-24.
  10. Kwansniewska A, Korobowicz E, Zdunek M, et al (2009). Prevalence of Chlamydia trachomatis and herpes simplex virus 2 in cervical carcinoma associated with human papillomavirus detected in paraffin-sectioned samples. Eur J Gynecol, 30, 65-70.
  11. Linda W (2002). Herpes simplex virus-2 may increase risk of cervical cancer. J Natl Cancer Inst, 94, 1591. https://doi.org/10.1093/jnci/94.21.1591
  12. Lulitanond V, Chantratita W, Thammaprasert K, et al (1994). Detection of herpes simplex virus type BglN fragment in paraffin - embeded cervical tissue section using nested polymerase chain reaction. Mol Cell Probes, 8, 441-7. https://doi.org/10.1006/mcpr.1994.1063
  13. Menczer J (2003). The low incidence of cervical cancer in Jewish women: has the puzzle finally been solved? Isr Med Assoc, 5, 120-3.
  14. Moradi N, Salehi R, Tamizifar H, et al (2005). Evaluation of co infection with human papilloma virus (HPV) and Herpes simplex virus in patients with various grades of cervical. J Isfahan Med School, 22, 24-32.
  15. Naserpour Farivar T, Johari P, Pahlavan AA, et al (2011). Agreement rate of rapid urease test, conventional PCR, and Scorpion real-time PCR in detecting Helicobacter pylori from tonsillar samples of patients with chronic tonsillitis. J Glob Infect Dis, 4, (in press).
  16. Newcomb WW, Brown JC (2009). Time dependent transformation of the herpesvirus tegument. J Virol, 83, 8082-9. https://doi.org/10.1128/JVI.00777-09
  17. Ohana B, Lipsen M,Vered S, et al (2000). Novel approach for specific detection of herpes simplex virus type 1 and 2 antibodies and immunoglobulin G and M antibodies. Clin Diagn Lab Immunol, 27, 904-8.
  18. Partridge JM, Koutsky LA (2006). Genital human papillomavirus infection in men. Lancet Infect Dis, 6, 21-31. https://doi.org/10.1016/S1473-3099(05)70323-6
  19. Smith J, Herrero R, Bosetti C, et al (2002). Herpes simplex virus 2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer. J Natl Cancer Inst, 94, 1604-13. https://doi.org/10.1093/jnci/94.21.1604
  20. Sapountzi-Krepia D, Roupa Z, Binioris S, et al (2001). Cervical intraepithelial dysplasia (CIN 3) and history of herpes genitalis (HSV2) in women living in Attica, Greece. In Vivo, 15, 525-8.
  21. Sawamura T, Kikuchi A, Wakayama Y, et al (2011). Evaluation and validation of a pretreatment method for automated genomic DNA and RNA extraction from clinical formalin-fixed paraffin-embeded samples using the MagNA Pure Compact System. Clin Lab, 57, 807-10.
  22. Szostek S, Zawilinska B, Klimek M, et al (2009). Is the presence of herpes virus in cervical secretions prognostic factor for cervical pathology in HPV-Positive women? Przel Epidemiol, 63, 97-101.
  23. Szostek S, Zawilinska B, Kopec J, et al (2009). Herpesviruses as possible co factors in HPV-16-related oncogenesis. Acta Biochim Pol, 56, 337-42.
  24. Yamakawa Y, Forslund O, Chva K, et al (1994). Detection of the BC24 transforming fragment of the herpes simplex virus type 2 (HSV-2) DNA in cervical carcinoma tissue by polymerase chain reaction. APMIS, 102, 401-6. https://doi.org/10.1111/j.1699-0463.1994.tb04890.x
  25. Uribe-Salas F, Conde-Glez CJ, Juarez-Figueroa L, et al (2003). Sociodemographic dynamics and sexually transmitted infections in female sex workers at the Mexican-Guatemalan border. Sex Transm Dis, 30, 266-71. https://doi.org/10.1097/00007435-200303000-00018
  26. Zereu M, Zettler C, Cambruzzi E, et al (2007). Herpes simplex virus type 2 and Chlamydia trachomatis in adenocarcinoma of the uterine cervix. Gynecol Oncol, 105, 172-5 https://doi.org/10.1016/j.ygyno.2006.11.006

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