Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Sex-related Differences in DNA Copy Number Alterations in Hepatitis B Virus-Associated Hepatocellular Carcinoma

  • Zhu, Zhong-Zheng (Department of Oncology, No. 113 Hospital of People's Liberation Army) ;
  • Wang, Dong (Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University) ;
  • Cong, Wen-Ming (Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University) ;
  • Jiang, Hongmei (Department of Statistics, Northwestern University) ;
  • Yu, Yue (Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University) ;
  • Wen, Bing-Ji (Department of Oncology, No. 113 Hospital of People's Liberation Army) ;
  • Dong, Hui (Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University) ;
  • Zhang, Xiao (Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University) ;
  • Liu, Shu-Fang (Parexel International) ;
  • Wang, Ai-Zhong (Department of Pathology, No. 113 Hospital of People's Liberation Army) ;
  • Zhu, Guanshan (Innovation Center China of AstraZeneca R&D) ;
  • Hou, Lifang (Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University)
  • Published : 2012.01.31
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Abstract

Background: Males have a higher prevalence of hepatocellular carcinoma (HCC) than females in general, but the reasons for the sex disparity are still obscure. DNA copy number alteration (CNA) is a major feature of solid tumors including HCC, but whether CNA plays a role in sex-related differences in HCC development has never been evaluated. Methods: High-resolution array comparative genomic hybridization (CGH) was used to examine 17 female and 46 male HCC patients with chronic hepatitis B virus (HBV) infection in Shanghai, China. Two-tailed Fisher's exact or ${\chi}^2$ tests was used to compare CNAs between females and males. Results: The overall frequencies and patterns of CNAs in female and male cases were similar. However, female HCC tumors presented more copy number gains compared to those in males on 1q21.3-q22 (76.5% vs. 37.0%, P = 0.009), 11q11 (35.3% vs. 0.0%, P = 0.0002) and 19q13.31-q13.32 (23.5% vs. 0.0%, P = 0.004), and loss on 16p11.2 (35.3% vs. 6.5%, P = 0.009). Relative to females, male cases had greater copy number loss on 11q11 (63.0% vs. 17.6%, P = 0.002). Further analyses showed that 11q11 gain correlated with 19q13.31-q13.32 gain (P = 0.042), 11q11 loss (P = 0.011) and 16p11.2 loss (P = 0.033), while 1q21.3-q22 gain correlated with 19q13.31-q13.32 gain (P = 0.046). Conclusions: These findings suggest that CNAs may play a role in sex-related differences in HBVassociated HCC development.

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References

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