Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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An Updated Pooled Analysis of Glutathione S-transferase Genotype Polymorphisms and Risk of Adult Gliomas

  • Yao, Lei (Department of Neurosurgery, The First Affiliated Hospital) ;
  • Ji, Guixiang (School of Public Health, Nanjing Medical University) ;
  • Gu, Aihua (School of Public Health, Nanjing Medical University) ;
  • Zhao, Peng (Department of Neurosurgery, The First Affiliated Hospital) ;
  • Liu, Ning (Department of Neurosurgery, The First Affiliated Hospital)
  • Published : 2012.01.31
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Abstract

Objective: Glutathione S-transferases (GSTs) are multifunctional enzymes that play a crucial role in the detoxification of both the endogenous products of oxidative stress and exogenous carcinogens. Recent studies investigating the association between genetic polymorphisms in GSTs and the risk of adult brain tumors have reported conflicting results. The rationale of this pooled analysis was to determine whether the presence of a GST variant increases adult glioma susceptibility by combining data from multiple studies. Methods: In our meta-analysis, 12 studies were identified by a search of the MEDLINE, HIGHWIRE, SCIENCEDIRECT and EMBASE databases. Of those 12, 11 evaluated GSTM1, nine evaluated GSTT1 and seven evaluated GSTP1 Ile105Val. Between-study heterogeneity was assessed using ${\chi}^2$-based Q statistic and the $I^2$ statistic. Crude odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to estimate the association between GSTM1, GSTT1 and GSTP1 polymorphisms and the risk of adult gliomas. Results: The quantitative synthesis showed no significant evidence to indicate an association exists between the presence of a GSTM1, GSTT1 or GSTP1 Ile105Val haplotype polymorphism and the risk of adult gliomas (OR, 1.008, 1.246, 1.061 respectively; 95% CI, 0.901-1.129, 0.963-1.611, 0.653-1.724 respectively). Conclusions: Overall, this study did not suggest any strong relationship between GST variants or related enzyme polymorphisms and an increased risk of adult gliomas. Some caveats include absence of specific raw information on ethnic groups or smoking history on glioma cases in published articles; therefore, well-designed studies with a clear stratified analysis on potential confounding factors are needed to confirm these results.

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References

  1. Alexandrie AK, Nyberg F, Warholm M, Rannug A (2004). Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population. Cancer Epidemiol Biomarkers Prev, 13, 908-14.
  2. Bailey LR, Roodi N, Verrier CS, et al (1998). Breast cancer and CYPIA1, GSTM1, and GSTT1 polymorphisms: evidence of a lack of association in Caucasians and African Americans. Cancer Res, 58, 65-70.
  3. Boccia S, La Torre G, Gianfagna F, et al (2006). Glutathione S-transferase T1 status and gastric cancer risk: a metaanalysis of the literature. Mutagenesis, 21, 115-23. https://doi.org/10.1093/mutage/gel005
  4. Cabelguenne A, Loriot MA, Stucker I, et al (2001). Glutathioneassociated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy. Int J Cancer, 93, 725-30. https://doi.org/10.1002/ijc.1392
  5. Chu HY, Wang ML, Shi D, et al (2011). Hsa-miR-196a2 Rs11614913 polymorphism contributes to cancer susceptibility: evidence from 15 case-control studies. PLoS ONE, 6, e18108. https://doi.org/10.1371/journal.pone.0018108
  6. Cotton SC, Sharp L, Little J, et al (2000). Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol, 151, 7-32. https://doi.org/10.1093/oxfordjournals.aje.a010124
  7. Coutinho P, Sandim V, Oliveira JA, et al (2010). Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro. Genet Mol Res, 9, 539-44. https://doi.org/10.4238/vol9-1gmr753
  8. Custodio AC, Almeida LO, Pinto GR, et al (2010). GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas. Genet Mol Res, 9, 2328-34. https://doi.org/10.4238/vol9-4gmr971
  9. da Fonte de Amorim L, Rossini A, Mendonça G, et al (2002). CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women. Cancer Lett, 181,179-86. https://doi.org/10.1016/S0304-3835(02)00058-7
  10. Dahabreh IJ, Giannouli S, Gota V, et al (2010). GSTT1 and GSTM1 polymorphisms and myelodysplastic syndrome risk: a systematic review and meta-analysis. Int J Cancer, 126, 1716-23.
  11. De Roos AJ, Rothman N, Inskip PD, et al (2003). Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev, 12, 14-22.
  12. Der Simonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  13. Egan KM, Cai Q, Shu XO, et al (2004). Genetic polymorphisms in GSTM1, GSTP1, and GSTT1 and the risk for breast cancer: results from the Shanghai breast cancer study and meta-analysis. Cancer Epidemiol. Biomarkers Prev, 13, 197-204. https://doi.org/10.1158/1055-9965.EPI-03-0294
  14. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. Bmj, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  15. Elexpuru-Camiruaga J, Buxton N, Kandula V, et al (1995). Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-Transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) Loci. Cancer Res, 55, 4237-9.
  16. Engel LS, Taioli E, Pfeiffer R, et al (2002). Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review. Am J Epidemiol, 156, 95-109. https://doi.org/10.1093/aje/kwf018
  17. Ezer R, Alonso M, Pereira E, et al (2002). Identification of glutathione S-transferase (GST) polymorphisms in brain tumors and association with susceptibility to pediatric astrocytomas. J Neuro-Oncol, 59, 123-34. https://doi.org/10.1023/A:1019601305210
  18. Gao LB, Pan XM, Li LJ, et al (2011). Null genotypes of GSTM1 and GSTT1 contribute to risk of cervical neoplasia: an evidence-based meta-analysis. PLoS ONE, 6, e20157. https://doi.org/10.1371/journal.pone.0020157
  19. Geisler SA, Olshan AF (2001). GSTM1, GSTT1, and the risk of squamous cell carcinoma of the head and neck: a mini-HuGE review. Am J Epidemiol, 154, 95-105. https://doi.org/10.1093/aje/154.2.95
  20. Gu D, Wang M, Wang M, et al (2009). The DNA repair gene APE1 T1349G polymorphism and cancer risk: a metaanalysis of 27 case-control studies. Mutagenesis, 24, 507-12. https://doi.org/10.1093/mutage/gep036
  21. Hand PA, Inskip A, Gilford J, et al (1996). Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. Carcinogenesis, 17, 1919-22. https://doi.org/10.1093/carcin/17.9.1919
  22. Hashibe M, Brennan P, Strange RC, et al (2003). Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer. Cancer Epidemiol. Biomarkers Prev, 12, 1509-17.
  23. Hung RJ, Boffetta P, Brennan P, et al (2004). GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population. Int J Cancer, 110, 598-604. https://doi.org/10.1002/ijc.20157
  24. Ioannidis JP, Rosenberg PS, Goedert JJ, et al (2002). Commentary: meta-analysis of individual participants' data in genetic epidemiology. Am J Epidemiol, 156, 204-10. https://doi.org/10.1093/aje/kwf031
  25. Kondratieva TV, Imyanitov EN, Togo AV, et al (2000). L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parameters of gliomas. J Exp Clin Cancer Res, 19, 197-200.
  26. Lai R, Crevier L, Thabane L (2005). Genetic polymorphisms of glutathione S-transferases and the risk of adult brain tumors: a meta-analysis. Cancer Epidemiol Biomarkers Prev, 14, 1784-90. https://doi.org/10.1158/1055-9965.EPI-05-0105
  27. Lau J, Ioannidis JP, Schmid CH (1997). Quantitative synthesis in systematic reviews. Ann Intern Med, 127, 820-6. https://doi.org/10.7326/0003-4819-127-9-199711010-00008
  28. Little J, Sharp L, Masson LF, et al (2006). Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland. Int J Cancer, 119, 2155-64. https://doi.org/10.1002/ijc.22093
  29. Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  30. Nebert DW, Vasiliou V (2004). Analysis of the glutathione S-transferase (GST) gene family. Hum Genomics, 1, 460-4. https://doi.org/10.1186/1479-7364-1-6-460
  31. Ntais C, Polycarpou A, Ioannidis JP (2005). Association of GSTM1, GSTT1, and GSTP1 gene polymorphisms with the risk of prostate cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev, 14, 176-81.
  32. Parl FF (2005). Glutathione S-transferase genotypes and cancer risk. Cancer Letters, 221, 123-9 https://doi.org/10.1016/j.canlet.2004.06.016
  33. Pearson WR, Vorachek WR, Xu SJ, et al (1993). Identification of class-A glutathione transferase genes GSTM1-GSTM5 on human chromo- some 1p13. Am J Hum Genet, 53, 220-33.
  34. Pinarbasi H, Siligb Y, Gurelik M (2005). Genetic polymorphisms of GSTs and their association with primary brain tumor incidence. Cancer Genetics and Cytogenetics, 156, 144-9. https://doi.org/10.1016/j.cancergencyto.2004.04.020
  35. Roodi N, Dupont WD, Moore JH, et al (2004). Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk. Cancer Res, 64, 1233-6. https://doi.org/10.1158/0008-5472.CAN-03-2861
  36. Schwartzbaum JA, Ahlbom A, Lonn S, et al (2007). An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev, 16, 559-65. https://doi.org/10.1158/1055-9965.EPI-06-0918
  37. Sorensen M, Autrup H, Tjonneland A, et al (2004). Glutathione s-transferase T1 null-genotype is associated with an increased risk of lung cancer. Int J Cancer, 110, 219-24. https://doi.org/10.1002/ijc.20075
  38. Taningher M, Malacarne D, Izzotti A, et al (1999). Drug metabolism polymorphisms as modulators of cancer susceptibility. Mutat Res, 436, 227-61. https://doi.org/10.1016/S1383-5742(99)00005-8
  39. Trizna Z, de Andrade M, Kyritsis AP, et al (1998). Genetic polymorphisms in glutathione S-transferase mu and theta, N-acetyltransferase, and CYP1A1 and risk of gliomas. Cancer Epidemiol Biomarkers Prev, 7, 553-5.
  40. Vogl FD, Taioli E, Maugard C, et al (2004). Glutathione S-transferases M1, T1, and P1 and breast cancer: a pooled analysis. Cancer Epidemiol Biomarkers Prev, 13, 1473-9.
  41. Wiencke JK, Wrensch MR, Miike R, et al (1997). Populationbased study of glutathione S-transferase mu gene deletion in adult glioma cases and controls. Carcinogenesis, 18, 1431-3. https://doi.org/10.1093/carcin/18.7.1431
  42. Wrensch M, Kelsey KT, Liu M, et al (2004). Glutathione-Stransferase variants and adult glioma. Cancer Epidemiol Biomarkers Prev, 13, 461-7.
  43. Zhang Z, Fu G, Wang M, et al (2008). P53 codon 72 polymorphism and ovarian cancer risk: a meta-analysis. J Nanjing Med University, 22, 279-85. https://doi.org/10.1016/S1007-4376(08)60080-5
  44. Zhang Z, Qiu L, Wang M, et al (2009). The FAS ligand promoter polymorphism, rs763110 (844C4T), contributes to cancer susceptibility: evidence from 19 case-control studies. Europ J Hum Genetics, 17, 1294-303. https://doi.org/10.1038/ejhg.2009.45
  45. Zhang Z, Xue H, Gong W, et al (2009). FAS promoter polymorphisms and cancer risk: a meta-analysis based on 34 case-control studies. Carcinogenesis, 30, 487-93. https://doi.org/10.1093/carcin/bgp016
  46. Zheng Y, Song HL, Higgins JP, et al (2006). Five glutathione S-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies. PLoS Med, 3, e91. https://doi.org/10.1371/journal.pmed.0030091
  47. Zhong S, Wyllie AH, Barnes D, et al (1993). Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis, 14, 1821-4. https://doi.org/10.1093/carcin/14.9.1821
  48. Zimniak P, Nanduri B, Pikula S, et al (1994). Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur J Biochem, 224, 893-9. https://doi.org/10.1111/j.1432-1033.1994.00893.x

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