Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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HPV Prevalence and Cervical Intraepithelial Neoplasia among HIV-infected Women in Yunnan Province, China: A Pilot Study

  • Zhang, Hong-Yun (Kunming Medical University) ;
  • Tiggelaar, Sarah M. (Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences) ;
  • Sahasrabuddhe, Vikrant V. (Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine) ;
  • Smith, Jennifer S. (Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina,) ;
  • Jiang, Cheng-Qin (Women and Children's Hospital of Luxi County) ;
  • Mei, Run-Bo (Women and Children's Hospital of Luxi County) ;
  • Wang, Xian-Guo (Women and Children's Hospital of Luxi County) ;
  • Li, Zu-An (Women and Children's Hospital of Luxi County) ;
  • Qiao, You-Lin (Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences)
  • Published : 2012.01.31
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Abstract

Objectives: To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China. Methods: Cervical cytology, HPV detection by Hybrid Capture-$2^{TM}$ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters. Results: Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with $cells/{\mu}L$ had higher CIN2+ prevalence after adjusting for current ART status and age (adjusted OR: 6.3, 95% CI: 1.1, 36.5). Conclusions: HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.

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References

  1. Zografos GN, Farfaras A, Zagouri F, Chrysikos D, Karaliotas K, (2011). Cholangiocarcinoma: principles and current trends. Hepatobiliary Pancreat Dis Int, 10, 10-20. https://doi.org/10.1016/S1499-3872(11)60001-5
  2. Belinson JL, Qiao YL, Pretorius RG, et al (2003). Shanxi Province cervical cancer screening study II: self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology. Int J Gynecol Cancer, 13, 819-26. https://doi.org/10.1111/j.1525-1438.2003.13611.x
  3. Belinson JL, Qiao YL, Pretorius RG, et al (2003). Shanxi Province cervical cancer screening study II: self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology. Int J Gynecol Cancer, 13, 819-26. https://doi.org/10.1111/j.1525-1438.2003.13611.x
  4. Denny L, Boa R, Williamson AL, et al (2008). Human papillomavirus infection and cervical disease in human immunodeficiency virus-1-infected women. Obstet Gynecol, 111, 1380-7. https://doi.org/10.1097/AOG.0b013e3181743327
  5. Dexeus S, Cararach M, Dexeus D (2002). The role of colposcopy in modern gynecology. Eur J Gynaecol Oncol, 23, 269-77.
  6. Franceschi S, Jaffe H (2007). Cervical cancer screening of women living with HIV infection: a must in the era of antiretroviral therapy. Clin Infect Dis, 45, 510-3. https://doi.org/10.1086/520022
  7. Gakidou E, Nordhagen S, Obermeyer Z (2008). Coverage of cervical cancer screening in 57 countries: low average levels and large inequalities. PLoS Med, 5, e132. https://doi.org/10.1371/journal.pmed.0050132
  8. Harrell FE, Jr., Lee KL, Matchar DB, Reichert TA (1985). Regression models for prognostic prediction: advantages, problems, and suggested solutions. Cancer Treat Rep, 69, 1071-7.
  9. Jia Y, Sun J, Fan L, et al (2008). Estimates of HIV prevalence in a highly endemic area of China: Dehong Prefecture, Yunnan Province. Int J Epidemiol, 37, 1287-96. https://doi.org/10.1093/ije/dyn196
  10. Joint United Nations Programme on HIV/AIDS and World Health Organization (2010). AIDS epidemic update.
  11. Kosinski AS, Barnhart HX (2003). Accounting for nonignorable verification bias in assessment of diagnostic tests. Biometrics, 59, 163-71. https://doi.org/10.1111/1541-0420.00019
  12. Lu L, Jia MH, Zhang XB, et al (2004). [Analysis for epidemic trend of acquired immunodeficiency syndrome in Yunnan Province of China]. Zhonghua Yu Fang Yi Xue Za Zhi, 38, 309-12.
  13. Luchters SM, Vanden Broeck D, Chersich MF, et al (2010). Association of HIV infection with distribution and viral load of HPV types in Kenya: a survey with 820 female sex workers. BMC Infect Dis, 10, 18. https://doi.org/10.1186/1471-2334-10-18
  14. Massad LS, Schneider M, Watts H, et al (2001). Correlating papanicolaou smear, colposcopic impression, and biopsy: results from the women's interagency HIV study. J Low Genit Tract Dis, 5, 212-8.
  15. Mwanahamuntu MH, Sahasrabuddhe VV, Stringer JS, Parham GP (2008). Integrating cervical cancer prevention in HIV/ AIDS treatment and care programmes. Bull World Health Organ, 86, D-E.
  16. Nanda K, McCrory DC, Myers ER, et al (2000). Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review. Ann Intern Med, 132, 810-9. https://doi.org/10.7326/0003-4819-132-10-200005160-00009
  17. Palefsky JM, Holly EA (2003). Chapter 6: Immunosuppression and co-infection with HIV. J Natl Cancer Inst Monogr, 31, 41-6.
  18. Pan Q, Belinson JL, Li L, et al (2003). A thin-layer, liquidbased pap test for mass screening in an area of China with a high incidence of cervical carcinoma. A cross-sectional, comparative study. Acta Cytol, 47, 45-50. https://doi.org/10.1159/000326474
  19. Qiao YL, Sellors JW, Eder PS, et al (2008). A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China. Lancet Oncol, 9, 929-36. https://doi.org/10.1016/S1470-2045(08)70210-9
  20. Richart RM (1973). Cervical intraepithelial neoplasia. Pathol Annu, 8, 301-28.
  21. Sahasrabuddhe VV, Mwanahamuntu MH, Vermund SH, et al (2007). Prevalence and distribution of HPV genotypes among HIV-infected women in Zambia. Br J Cancer, 96, 1480-3. https://doi.org/10.1038/sj.bjc.6603737
  22. Sahasrabuddhe VV, Bhosale RA, Joshi SN, et al (2010). Prevalence and predictors of colposcopic-histopathologically confirmed cervical intraepithelial neoplasia in HIV-infected women in India. PLoS One, 5, e8634. https://doi.org/10.1371/journal.pone.0008634
  23. Sahasrabuddhe VV, Bhosale RA, Kavatkar AN, et al (2011). Comparison of visual inspection with acetic acid (VIA) and cervical cytology to detect high grade cervical neoplasia among HIV-infected women in India. Int J Cancer, 130, 234-40. https://doi.org/10.1002/ijc.25971
  24. Shi JF, Canfell K, Lew JB, Qiao YL (2012). The burden of cervical cancer in China: Synthesis of the evidence. Int J Cancer, 130, 641-52. https://doi.org/10.1002/ijc.26042
  25. Strickler HD, Burk RD, Fazzari M, et al (2005). Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst, 97, 577-86. https://doi.org/10.1093/jnci/dji073
  26. Terry G, Ho L, Londesborough P, et al (2001). Detection of high-risk HPV types by the hybrid capture 2 test. J Med Virol, 65, 155-62. https://doi.org/10.1002/jmv.2015
  27. Ting J, Kruzikas DT, Smith JS (2010). A global review of agespecific and overall prevalence of cervical lesions. Int J Gynecol Cancer, 20, 1244-9. https://doi.org/10.1111/IGC.0b013e3181f16c5f
  28. Tornesello ML, Duraturo ML, Giorgi-Rossi P, et al (2008). Human papillomavirus (HPV) genotypes and HPV16 variants in human immunodeficiency virus-positive Italian women. J Gen Virol, 89, 1380-9. https://doi.org/10.1099/vir.0.83553-0
  29. Videla S, Darwich L, Canadas MP, et al (2009). Epidemiological data of different human papillomavirus genotypes in cervical specimens of HIV-1-infected women without history of cervical pathology. J Acquir Immune Defic Syndr, 50, 168-75. https://doi.org/10.1097/QAI.0b013e3181938e63
  30. Yu ES, Xie Q, Zhang K, Lu P, Chan LL (1996). HIV infection and AIDS in China, 1985 through 1994. Am J Public Health, 86, 1116-22. https://doi.org/10.2105/AJPH.86.8_Pt_1.1116
  31. Zhang L, Chen Z, Cao Y, et al (2004). Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china. J Virol, 78(24), 13591-9. https://doi.org/10.1128/JVI.78.24.13591-13599.2004
  32. Zhang Y, Lu L, Ba L, et al (2006). Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med, 3, e443. https://doi.org/10.1371/journal.pmed.0030443
  33. Zheng X, Tian C, Choi KH, et al (1994). Injecting drug use and HIV infection in southwest China. AIDS, 8, 1141-7. https://doi.org/10.1097/00002030-199408000-00017
  34. Zheng XW (1991). A preliminary study on the behavior of 225 drug abusers and the risk factors of HIV infection in Ruili county Yunnan Province. Zhonghua Liu Xing Bing Xue Za Zhi, 12, 12-4 (in Chinese).

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