Korean Chemical Engineering Research

The Korean Institute of Chemical Engineers (한국화학공학회)
권호 표지
DOI QR코드

DOI QR Code

The Effect of Fcoidan Molecula Weight on Cosmetic Function

후코이단의 분자량이 화장품기능성에 미치는 영향

  • Received : 2012.01.02
  • Accepted : 2012.02.13
  • Published : 2012.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

Properties of fucoidan used for functional cosmetic ingredients and the effect of fucoidan molecular weight on the cosmetic functions were studied. Fucoidan was extracted from Undaria pinnatifida sporophylls and molecular weight (35~160 kDa) of fucoidan was controlled by contact glow discharge electrolysis (CGDE). To test possibility of fucoidan as a cosmetics material, tyrosinase inhibition property, water-holding property, elastase activity inhibition property and DPPH free radical scavenging property were measured. Water-holding property of fucoidan was higher than that of hyaruronic acid, which is known as the one of the best water-holding material. The water-holding strength of fucoidan slightly increase as molecular weight of fucoidan decrease. Elastase activity inhibition (anti wrinkle effect) of fucoidan was higher than that of adenosine using standard material for anti wrinkle test. Optimum molecular weight of fucoidan to obtain highest tyrosin inhibition effect, elastase inhibition effect and radical scavenger effect is 100 kDa.

기능성화장품 소재로 사용하기 위한 후코이단의 특성 및 후코이단 분자량의 영향에 대해 연구하였다. 후코이단은 미역 포자엽에서 추출하였고 접촉글로우방전 전기분해(CGDE)방법에 의해 후코이단 분자량(35~160 kDa)을 조절하였다. 후코이단의 tyrosinase inhibition, 보습력, elastase 활성저해 효과와 항산화력(DPPH assay, radical scavenging)을 측정하여 화장품으로서 가능성을 확인하였다. 후코이단의 보습력은 최고의 보습제 중의 하나인 히아루론산의 보습력보다 높았고, 분자량이 감소함에 따라 보습력이 약간 증가하였다. 주름개선 효과실험인 elastase 활성저해 효과 실험결과 표준 비교물질인 adenosine 보다 높은 elastase 활성저해 효과를 보였다. 최고의 tyrosinase 저해효과, elastase 활성저해 효과, 항산화력(DPPH assay, radical scavenging)을 갖는 후코이단의 분자량은 100 kDa이었다.

Keywords

References

  1. Tatiana, N. Z., Nataliiya, M. S., Irina, B. P., Vladimir, V. I., Andrey, S. S., Elena, V. S. and Lyudmila, A. E., "A New Procedure for the Separation of Water-Soluble Polysaccharides from Brown Seaweeds," Carbohydr. Res., 322, 32-39(1999). https://doi.org/10.1016/S0008-6215(99)00206-2
  2. Fortun, A., Khalil, A., Gagne, D., Douziech, N., Kuntz, C. and Dupuis, G., "Monocytes Influence the Fate of T Cells Challenged with Oxidised Low Density Lipoproteins Towards Apoptosis or MHC-Restricted Proliferation," Atherosclerosis, 156, 11-21(2001). https://doi.org/10.1016/S0021-9150(00)00575-X
  3. Collis, S., Fisher. A. M., Tapon-Bretaudiere, J., Boisson, C., Durand, P. and Jozefonvicz, J., "Anticoagulant Properties of a Fucoidan Fraction," Thtombosis Research, 64(2), 143-154(1991). https://doi.org/10.1016/0049-3848(91)90114-C
  4. Mauray, S., Raucourt, E., Talbot, J., Jozefowicz, M. and Fischer, A., "Mechanism of Factor IXa Inhibition by Antithrombin in the Presence of Unfractionated and Low Molecular Weight Heparins and Fucoidan," Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology, 1387(1-2), 184-194(1998). https://doi.org/10.1016/S0167-4838(98)00120-4
  5. Saito, A., Yoneda, M., Yokohama, S., Okada, M., Haneda, M. and Nakamura, K., "Fucoidan Prevents Concanavalian A-Induced Liver Injury Through Induction of Endogenous 1L-10 in Mice," Hepatology Research, 35(3), 190-198(2006).
  6. Moon, H. J., Lee, S. R., Shim, S. N., Jeong, S. H., Stonik, V. A., Rasskazov, V. A., Zvyagintsva, T. and Lee, Y. H., "Fucoidan Inhibits UVB-induced MMP-1 Expression in Human Skin Fibroblasts," Biol. Pharm Bull., 31, 284-289(2008). https://doi.org/10.1248/bpb.31.284
  7. O'Leary, R., Rerrk, M., Wood, E. J., "Fucoidan Modulates the Effect of Transforming Growth Factor(TGF)-beta 1 on Fibroblast Proliferation and Wound Repopulation in in vitro Models of Dermal Wound Repair," Biol. Pharm Bull., 27, 266-270(2004). https://doi.org/10.1248/bpb.27.266
  8. Oomizu, S., Yanase, Y., Suzuki, H., Kameyoshi, Y. and Hide, M., "Fucoidan prevents Ce Germline Transcription and NFjB p52 Translocation for IgE Production in B Cells," Biochem. Biophys. Res. Commun., 350, 501-507(2006). https://doi.org/10.1016/j.bbrc.2006.08.009
  9. Cha, S. H., Lee, J. S., Kim, Y. S., Kim, D. U., Moon, J. C. and Park, K. P., "Properties of Fucoidan as Raw Materials of Waterholding Cream and Cosmetics," Korean Chem. Eng. Res. (HWAHAK KONGHAK), 48(1), 27-32(2010).
  10. Alain, N., Frederic C., Catherine,B-V., Patrick, D. and Jacquline, J., "Anticoagulant Low Molecular Weight Fucans Produced by Radical Process and ion Exchange Chromatography of High Molecular Weight Fucans Extracted from the Brown Seaweed Ascophyllum Nodusum," Carbohydr. Res., 289, 201-208 (1996). https://doi.org/10.1016/0008-6215(96)00110-3
  11. Lionel, C., Alain, F., Frederic., C., Nelly, K., Corinne, S., Anne- Marie, F. and Catherine, B., "Further Data on the Structure of Brown Seaweed Fucans: Relationships with Anticoagulant Activity," Carbohydr. Res., 319, 154-165(1999). https://doi.org/10.1016/S0008-6215(99)00127-5
  12. Regis, D., Olivier, B., Jacqueline, J. and Nicole, G., "Degrada-tion of Algal(Ascophyllum nodusom) Fucoidan by An Enzymatic Activity Contained in Digestive Glands of the Marine Molluse Pecten Maximus," Carbohydr. Res., 322, 291-297(1999). https://doi.org/10.1016/S0008-6215(99)00223-2
  13. Bae, J. S., Lee, J. S., Kim, Y. S., Sim, W. J., Lee, H., Chun, J. Y. and Park, K. P., "Depolymerization of Fucoidan by Contact Glow Discharge Electrolysis (CGDE)," Korean Chem. Eng. Res. (HWAHAK KONGHAK), 46(5), 886-891(2008).
  14. Susanta, K. S., Rajeshwar, S. and Ashok, K. S., "A Study on the Origin of Nonfaradaic Behavior of Anodic Contact Glow Discharge Electrolysis," J. Electrochem. Soc., 145(7), 2209-2213 (1998). https://doi.org/10.1149/1.1838621
  15. Dodgson, K. S., "Determination of Inorganic Sulphate in Studies on the Enzymic and Non-enzymic Hydrolysis of Carbohydrate and Other Sulphate Esters," Biochem. J., 78, 312(1961). https://doi.org/10.1042/bj0780312
  16. Kim, T. H., Lee, J. H., Cho, G. J. and Park, K. P., "Degradation of Nafion Membrane by Oxygen Radical," Korean Chem. Eng. Res. (HWAHAK KONGHAK), 44(6), 597-601(2006).
  17. Jung, S. H., Effect of Fucoidan Extracted from Seaweeds as a Skin Whitener, Graduate School, Kosin University, Phd thesis (2008).
  18. Senni, K., Gueniche, F., Foucault-Bertaud, A., Gondjo-Tchen, S., Fioretti, F., Colliec-Jouault, S., Durand, P., Guezennec, J., Godeau, G. and Letourneur, D., "Fucoidan a Sulfated Polysaccharide from Brown Algae is a Potent Modulator of Connective Tissue Proteolysis," Arch. Biochem. Biophys., 445, 56-64(2006). https://doi.org/10.1016/j.abb.2005.11.001
  19. Houa, Y., Wang, J., Jin, W., Zhang, H. and Zhang, Q., "Degradation of Laminaria Japonica Fucoidan by Hydrogen Peroxide and Antioxidant Activities of the Degradation Products of Different Molecular Weights," Carbohydr. Polym., 87, 153-159(2012). https://doi.org/10.1016/j.carbpol.2011.07.031
  20. de Souza, M. C. R., Marques, C. T., Dore, C. M. G., da Silva, F. R. F., Rocha, H. A. O. and Leite, E. L., "Antioxidant Activities of Sulfated Polysaccharides from Brown and Red Seaweeds," J. Appl. Phycol., 19(2), 153-160(2007). https://doi.org/10.1007/s10811-006-9121-z

Cited by

  1. Protective Effect of Mulberry and Lithospermum erythrorhizon Extracts on Anti-aging against Photodamage vol.42, pp.11, 2013, https://doi.org/10.3746/jkfn.2013.42.11.1744
  2. 좌금환과 수련환의 항균, 항산화 및 미백 효과 vol.30, pp.2, 2012, https://doi.org/10.6114/jkood.2017.30.2.100
  3. 불등풀가사리 다당류의 분자량에 따른 이화학적 품질특성 및 피부 주름 개선 효과 vol.24, pp.5, 2012, https://doi.org/10.11002/kjfp.2017.24.5.688
  4. 꼬시래기 유래 Polysaccharide의 보습유지 및 피부개선효과 vol.9, pp.2, 2012, https://doi.org/10.15433/ksmb.2017.9.2.058
  5. 커피 에탄올 추출물의 항균 및 미백활성 vol.56, pp.2, 2012, https://doi.org/10.9713/kcer.2018.56.2.245
  6. 후코이단에 의한 PEMFC 고분자막의 열화 감소 vol.58, pp.1, 2012, https://doi.org/10.9713/kcer.2020.58.1.59