Preventive Nutrition and Food Science

  • 제17권1호
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  • Pages.78-82
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  • 2012
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  • 2287-1098(pISSN)
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  • 2287-8602(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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The Antithrombotic and Fibrinolytic Effect of Natto in Hypercholesterolemia Rats

  • Park, Kum-Ju (The Food and Culture Institute, Pulmuone Holdings) ;
  • Kang, Jung-Il (The Food and Culture Institute, Pulmuone Holdings) ;
  • Kim, Tae-Seok (The Food and Culture Institute, Pulmuone Holdings) ;
  • Yeo, Ik-Hyun (The Food and Culture Institute, Pulmuone Holdings)
  • 투고 : 2011.12.07
  • 심사 : 2012.02.27
  • 발행 : 2012.03.31
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초록

Antithrombotic and fibrinolytic activity of natto was evaluated on platelet aggregation in vitro and in vivo. Natto showed inhibitory effects on platelet aggregation induced by adenosine 5’diphosphate (ADP) and collagen. Orally administered natto also showed fibrinolytic activity in hypercholesterolemia rats. Normal levels of natto, when administered for four weeks, shortened euglobulin clot lysis time (ECLT) and prolonged partial thromboplastin time (PATT) significantly compared to non-treated group. In addition, the natto treatment decreased total cholesterol in serum. These results showed that intake of normal levels of natto can elicit antithrombotic and fibrinolytic effects, suggesting its consumption may improve blood circulation.

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참고문헌

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피인용 문헌

  1. Health Benefits of Fermented Foods 2019, https://doi.org/10.1080/10408398.2017.1383355
  2. Biotransformed product, genistein 7-O-phosphate, enhances the oral bioavailability of genistein vol.13, 2015, https://doi.org/10.1016/j.jff.2015.01.008
  3. Effect of black soybean natto extract (Glycine soja) on reproduction system of hypercholesterolemia male mice vol.5, pp.5, 2016, https://doi.org/10.1016/j.apjr.2016.08.002
  4. vol.32, pp.1, 2018, https://doi.org/10.1080/08905436.2017.1413986
  5. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases vol.13, pp.1177-2719, 2018, https://doi.org/10.1177/1177271918785130
  6. Effects of a high-γ-polyglutamic acid-containing natto diet on liver lipids and cecal microbiota of adult female mice vol.40, pp.4, 2012, https://doi.org/10.12938/bmfh.2020-061
  7. Thrombolytic Enzymes of Microbial Origin: A Review vol.22, pp.19, 2021, https://doi.org/10.3390/ijms221910468