Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Force-induced Unbinding Dynamics in a Multidimensional Free Energy Landscape

  • Received : 2011.11.30
  • Accepted : 2012.01.05
  • Published : 2012.03.20
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Abstract

We examined theory for force-induced unbinding on a two-dimensional free energy surface where the internal dynamics of biomolecules is coupled with the rupture process under constant tension f. We show that only if the transition state ensemble is narrow and activation barrier is high, the f-dependent rupture rate in the 2D potential surface can faithfully be described using an effective 1D energy profile.

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References

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