Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products Formation (VII)

한국약용식물의 최종당화산물 생성저해활성 검색(VII)

  • Choi, So-Jin (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Young Sook (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Song, Yoo Jin (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Yun Mi (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Joo Hwan (Department of Life Science, Gachon University) ;
  • Kim, Jin Sook (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
  • 최소진 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 김영숙 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 송유진 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 이윤미 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 김주환 (가천대학교 생명과학과) ;
  • 김진숙 (한국한의학연구원 한약연구본부 한의신약연구그룹)
  • Received : 2012.09.24
  • Accepted : 2012.12.07
  • Published : 2012.12.31
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Abstract

In this study, 49 Korean herbal medicines have been investigated with an in vitro evaluation system using glycation end products (AGEs) formation inhibitory activity. Of these, 18 herbal medicines ($IC_{50}$ < $50{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Of these, five herbal medicines ($IC_{50}$ < $50{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, Mallotus japonicus (twigs and leaves), Rhus javanica (twigs and leaves), Boehmeria nivea (whole plants), Quercus acuta (stems), and Eurya japonica (stems) showed more potent inhibitory activity (approximately 9-37 fold) than the positive control aminoguanidine ($IC_{50}=76.47{\mu}g/ml$).

Keywords

References

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