Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Antioxidant Constituents of the Aerial Parts of Curcuma longa

강황 지상부의 항산화 성분

  • Received : 2012.10.20
  • Accepted : 2012.11.06
  • Published : 2012.12.31
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Abstract

As part of ongoing study focused on the discovery of natural antioxidants from Korean plants by measuring the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging effect and superoxide quenching activity, ethanol extract of the aerial parts of Curcuma longa (Zingiberaceae) was found to show potent antioxidant activities. Subsequent activity-guided fractionation of the ethanol extract led to the isolation of two phenolic compounds, 1,2,3,4,6-penta-O-galloyl-${\beta}$-D-glucopyranoside (1) and gallic acid (2), as antioxidant compounds. Their structures were elucidated by spectroscopic studies. Compounds 1 and 2 were isolated for the first time from this plant. These compounds showed the significant antioxidative effects during the DPPH free radical scavenging test, and the riboflavin- and xanthine-originated superoxide quenching activity tests.

Keywords

References

  1. Steinmetz, K. A. and Potter, J. D. (1991) Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Contrl. 2: 427-442. https://doi.org/10.1007/BF00054304
  2. Woo, K. S., Seo, M. C., Kang, J. R., Ko, J. Y., Song, S. B., Lee, J. S., Oh, B. G., Park, G. D., Lee, Y. H., Nam, M. H. and Jeong, H. S. (2010) Antioxidant compounds and antioxidant activities of the methanolic extracts from milling fractions of sorghum (Sorghum bicolor L. Moench). J. Korean Soc. Food Sci. Nutr. 39: 1695-1699. https://doi.org/10.3746/jkfn.2010.39.11.1695
  3. Yu, B. P. (1996) Aging and oxidative stress: modulation by dietary restriction. Free Radic. Biol. Med. 21: 651-668. https://doi.org/10.1016/0891-5849(96)00162-1
  4. Heo, C., Chung, J. H., Jo, B. K., Kim, H. P. and Heo, M. Y. (2003) Antioxidative activities of 60 plant extracts. The Journal of Applied Pharmacology 11: 196-199.
  5. Heo, C., Chung, J. H., Jo, B. K., Kim, H. P. and Heo, M. Y. (2003) Antioxidative activities of 60 plant extracts. The Journal of Applied Pharmacology 11: 196-199.
  6. Suk, S. H. (2006) Antioxidant effect of vitamin E on vascular endothelial cells damaged by reactive oxygen species. Korean J. Oriental Physiology & Pathology 20: 685-689.
  7. 한국약학대학협의회 약전분과회 편저 (2008) 대한약전해설서(9개정) II, 1098, 1161, 도서출판 신일북스, 서울.
  8. Yoshida, T., Mori, K., Hatano, T., Okumura, T., Uehara, I., Komagoe, K., Fujita, Y. and Okuda, T. (1989) Studies on inhibition mechanism of autooxidation by tannins and flavonoids. V.- Radical scavenging effects of tannins and related polyphenols on 1,1-diphenyl-2-picrylhydrazyl radical. Chem. Pharm. Bull. 37: 1919-1921. https://doi.org/10.1248/cpb.37.1919
  9. Choi, D. S., Kim, S. J., and Jung, M. Y. (2001) Inhibitory activity of berberine on DNA strand cleavage induced by hydrogen peroxide and cytochrome c. Biosci. Biotechnol. Biochem. 65: 452-455. https://doi.org/10.1271/bbb.65.452
  10. Ginnopolitis, C. N. and Ries, S. K. (1977) Superoxide dismutase. I. Occurrence in higher plants. Plant Physiol. 59, 309-314. https://doi.org/10.1104/pp.59.2.309
  11. Thuong, P. T., Su, N. D., Ngoc, T. M., Hung, T. M., Dang, N. H., Thuan, N. D., Bae, K. H. and Oh, W. K. (2009) Antioxidant activity and principles of Vietnam bitter tea Ilex kudingcha. Food Chem. 113: 139-145. https://doi.org/10.1016/j.foodchem.2008.07.041
  12. Kim, J. J., Lee, J. S., Kim S. Y., Kim, J. A., Chung, S. R., Jang, T. S. and Lee, S. H. (2001) Inhibitory effect of hydrolysable tannins isolated from the Euphorbia helioscopia on mushroom tyrosinase activity in vitro. Yakhak Hoeji 45: 214-219.
  13. Park, W. Y., Lee, S. C., Ahn, B. T., Lee, S. H., Ro, J. S. and Lee, K. S. (1993) Phenolic compounds from Acalypha australis L. Kor. J. Pharmacogn. 24: 20-25.
  14. Kim, J. K., Kwon, D. J., Lim, S. S. and Bae, Y. S. (2010) Chemical constituents of domestic Quercus spp. barks. Mokchae Konghak 38: 359-374.