Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
권호 표지

Long-Term Complete Remission in an Acute Myeloid Leukemia Patient with Isolated Central Nervous System Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

급성골수성 백혈병에서 동종조혈모세포 이식 후 고립성 중추신경계 재발에서의 장기 완전 관해 1예

  • Kim, Myung Jin (Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Ko, Sung Ae (Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Jang, Hyo Jin (Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Jeong, Da Eun (Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Park, Jeung Min (Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Lee, Kyoung Hee (Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Kim, Min Kyoung (Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Bae, Young Kyung (Division of Hematology-Oncology, Department of Pathology, College of Medicine, Yeungnam University) ;
  • Hyun, Myung Soo (Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University)
  • 김명진 (영남대학교 의과대학 내과학교실) ;
  • 고성애 (영남대학교 의과대학 내과학교실) ;
  • 장효진 (영남대학교 의과대학 내과학교실) ;
  • 정다은 (영남대학교 의과대학 내과학교실) ;
  • 박정민 (영남대학교 의과대학 내과학교실) ;
  • 이경희 (영남대학교 의과대학 내과학교실) ;
  • 김민경 (영남대학교 의과대학 내과학교실) ;
  • 배영경 (영남대학교 의과대학 병리학교실) ;
  • 현명수 (영남대학교 의과대학 내과학교실)
  • Received : 2012.04.27
  • Accepted : 2012.06.08
  • Published : 2012.12.31
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Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is considered the optimal curative treatment for acute myeloid leukemia (AML), but some patients develop bone marrow relapse due to remnant leukemia, and few patients develop extramedullary relapse without bone marrow relapse. Isolated extramedullary relapse (IMER) is defined as extramedullary relapse without bone marrow relapse. IMER has been reported in various sites, including the skin, soft tissue, and central nervous system(CNS). Isolated CNS relapse is relatively rare and is associated with poor prognosis due to the absence of an optimal treatment for it. Reported herein is a case involving an adult AML woman who suffered from isolated extramedullary relapse in the CNS after allogeneic HSCT. She was treated with intrathecal chemotherapy and whole-brain and spine radiotherapy, followed by systemic chemotherapy. She is currently well, with no evidence of leukemia recurrence for over six years.

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