Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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The Efficacy of Oral Low Molecular Weight Collagen Peptide for Skin Recovery after Fractional Photothermolysis Laser Treatment

Fractional Photothermolysis 치료 후 피부회복 촉진에 미치는 경구용 저분자 콜라겐 펩타이드의 효과

  • Kim, In Su (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Choi, Sun Young (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, Byung Gyu (Beutyfood Research Institute, Amorepacific Corporation R&D Center) ;
  • Kim, Jeong Kee (Beutyfood Research Institute, Amorepacific Corporation R&D Center) ;
  • Kim, Eun Joo (Skin Research Institute, Amorepacific Corporation R&D Center) ;
  • Kim, Beom Joon (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, Myeung Nam (Department of Dermatology, Chung-Ang University College of Medicine)
  • 김인수 (중앙대학교 의과대학 피부과학교실) ;
  • 최선영 (중앙대학교 의과대학 피부과학교실) ;
  • 김병규 ((주)아모레퍼시픽 뷰티푸드연구소) ;
  • 김정기 ((주)아모레퍼시픽 뷰티푸드연구소) ;
  • 김은주 ((주)아모레퍼시픽 피부과학연구소) ;
  • 김범준 (중앙대학교 의과대학 피부과학교실) ;
  • 김명남 (중앙대학교 의과대학 피부과학교실)
  • Received : 2012.07.28
  • Accepted : 2012.12.17
  • Published : 2012.12.30
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Abstract

Recent studies have revealed that collagen peptide plays a protective role on skin by improving the activity of antioxidants and acts as an inducer of skin regeneration. To evaluate the efficacy of low molecular weight collagen peptide for skin recovery after non-ablative 1550 nm fractional photothermolysis laser. 10 volunteers were randomly divided into two groups. Both control and experimental groups received fractional photothermolysis treatment. In the experimental group, 5 subjects received oral collagen peptide 1,000 mg/day for 8 weeks. Before and after the treatment, we measured elastic recovery of skin, transepidermal water loss (TEWL) and erythema index (EI) for each patients. The evaluation of clinical results showed that elastic recovery of skin is higher in the experimental group than the control group (p < 0.05). TEWL have no significancy between two groups and erythema rapidly disappeared in the experimental group. On the quartile grading scale, the mean patient satisfaction 4 weeks after the fractional photothermolysis treatment was 2.0 in experimental group and 1.2 in control group. The low molecular weight collagen peptide appears to be an effective conservative therapy for skin recovery after non-ablative 1550 nm fractional photothermolysis treatment.

최근에는 콜라겐 펩타이드가 항상화효과를 통해 피부의 재생을 촉진시키는 효과를 한다는 연구가 보고되고 있다. 본 구는 저분자 경구 콜라겐 펩타이드가 1550 nm fractional photothermolysis 레이저 치료 후 피부재생에 미치는 영향을 알아보고자 한다. 본 실험에 참여한 환자는 총 10명으로 실험군과 대조군 각 5명씩 무작위배정되었다. 대조군과 실험군 모두 동일하게 fractional photothermolysis 레이저를 시술받았다. 실험군에서는 경구 콜라겐 펩타이드를 하루에 1,000 mg씩 총 8주간 복용하였다. 치료 전후 모든 환자에서 피부의 탄성도, 경표피수분손실도, 홍반지수를 측정하였다. 피부탄성도는 실험군에서 대조군에 비해 통계적으로 유의하게 피부의 탄력성이 증가하였음을 확인하였다(p < 0.05). 경표피수분손실도는 두군간에 유의한 차이가 없었고, 홍반지수는 실험군에서 더 빨리 감소하는 결과를 보였다. 환자의 주관적 만족도평가에서 시술 4주 후 환자의 만족도는 실험군에서 평균 2.0점, 대조군에서 1.2점으로 나타났다. 저분자 콜라겐 펩타이드는 1550 nm fractional photothermolysis 레이저 치료 후 피부회복 촉진에 도움이 된다.

Keywords

References

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