Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Cholinesterase Inhibitory Constituents from Capsosiphon fulvescens

  • Fang, Zhe (College of Pharmacy, Catholic University of Daegu) ;
  • Jeong, Su Yang (College of Pharmacy, Catholic University of Daegu) ;
  • Choi, Jae Sue (Division of Food Science and Biotechnology, Pukyong National University) ;
  • Min, Byung Sun (College of Pharmacy, Catholic University of Daegu) ;
  • Min, Bo Kyung (College of Pharmacy, Catholic University of Daegu) ;
  • Woo, Mi Hee (College of Pharmacy, Catholic University of Daegu)
  • Received : 2012.09.13
  • Accepted : 2012.11.01
  • Published : 2012.12.31
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Abstract

Nine compounds (1 - 9), ${\alpha}$-linolenic acid (1), cis-5,8,11,14,17-elcosapentaenoic acid (2), phytol (3), loliolide (4), uridine (5), thymidine (6), deoxyadenosine (7), adenine (8), and adenosine (9), were isolated from the n-hexane, methylene chloride, ethyl acetate and n-butanol fractions of Capsosiphon fulvescens. The structures of these compounds were elucidated on the basis of spectroscopic evidence. Compounds 1 - 9 exhibited acetylcholinesterase (AChE) inhibitory activities with $IC_{50}$ values ranging from 114.91 to $252.40{\mu}M$, whereas 2 - 4 showed butyrylcholinesterase (BChE) inhibitory activities with $IC_{50}$ values ranging from 251.18 to $499.16{\mu}M$.

Keywords

References

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