Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
권호 표지
DOI QR코드

DOI QR Code

Discovery of Novel 1,4-Benzodioxane Containing Thiazolidinone Derivatives as Potential Antihepatotoxic Agent

  • Received : 2011.11.02
  • Accepted : 2011.12.14
  • Published : 2012.02.20
Download PDF
⟨ Previous Next ⟩

Abstract

In continuance of our search for newer antihepatotoxic agents some novel thiazolidinone derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were evaluated for antihepatotoxic activity against $CCl_4$-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin.

Keywords

References

  1. Radha, K. D.; Yogesh, K. C. Dig. Dis. Sci. 2005, 50, 1807. https://doi.org/10.1007/s10620-005-2942-9
  2. Venkateswaran, S.; Pari, L.; Viswanathan, P.; Menon, V. P. J. Ethnopharmacol. 1997, 57, 161. https://doi.org/10.1016/S0378-8741(97)00062-7
  3. Latha, U.; Rajesh, M. G.; Latha, M. S. Indian Drugs. 1999, 36, 470.
  4. Mitra, S. K.; Seshadri, S. J.; Venkataranganna, M. V.; Gopumadhavan, S.; Udupa, V.; Sarma, D. N. K. Ind. J. Physiol. Pharmacol. 2000, 44, 82.
  5. Dhuley, J. N.; Naik, S. R. J. Ethnopharmacol. 1997, 56, 159. https://doi.org/10.1016/S0378-8741(97)01524-9
  6. Ahmed, B.; Khan, S. A.; Alam, T. Pharmazie. 2003, 58, 173.
  7. Khan, S. A.; Ahmed, B.; Alam, T. Pak. J. Pharm. Sci. 2006, 19, 290.
  8. Ahmed, B.; Habibullah.; Khan, S. J. Enz. Inh. Med. Chem. 2011, 26, 216. https://doi.org/10.3109/14756366.2010.489899
  9. Chapleo, C. B.; Myers, P. L.; Butler, C. M.; Doxey, J. C.; Roach, A. G. J. Med. Chem. 1983, 26, 823. https://doi.org/10.1021/jm00360a008
  10. Vazquez, M. T.; G. Rosell, M. D. Pujol. Eur. J. Med. Chem. 1997, 32, 529. https://doi.org/10.1016/S0223-5234(97)84016-0
  11. Birch, A. M.; Bardley, P. A.; Gill, J. C.; Kerrigan, F.; Needham, P. L. J. Med. Chem. 1999, 42, 3342. https://doi.org/10.1021/jm9910122
  12. Satzinger, G.; Herrmann, M. U. S. Patent 4,018,775, Apr. 19, 1977.
  13. Khalilullah, H.; Khan, S.; Ahsan, M. J.; Ahmed, B. Bioorg. Med. Chem. Lett. 2011, 21, 7251. https://doi.org/10.1016/j.bmcl.2011.10.056
  14. Reitman, S.; Frankel, S. Am. J. Clin. Pathol. 1957, 28, 56. https://doi.org/10.1093/ajcp/28.1.56
  15. Kind, P. R. N.; King, E. J. J. Clin. Pathol. 1954, 7, 322. https://doi.org/10.1136/jcp.7.4.322
  16. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. J. Biol. Chem. 1951, 193, 265.

Cited by

  1. Synthesis of new 4-amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol derivatives vol.53, pp.3, 2017, https://doi.org/10.1134/S1070428017030198
  2. Non-peripherally tetra substituted phthalocyanines bearing benzodioxane moieties: Synthesis, characterization and investigation of electrochemical and spectroelectrochemical properties vol.1189, pp.None, 2012, https://doi.org/10.1016/j.molstruc.2019.04.031
  3. Synthesis and Antibacterial Activity of New Oxadiazolylbenzodioxane Derivatives vol.56, pp.3, 2012, https://doi.org/10.1134/s1070428020030033
  4. Octa-substituted metallophthalocyanines bearing (2,3-dihydrobenzo-1,4-benzodioxin-2-yl)methoxy and chloro groups: Synthesis, characterization and photophysicochemical studies vol.24, pp.4, 2012, https://doi.org/10.1142/s1088424620500030