Bulletin of the Korean Chemical Society

  • 제33권2호
  • /
  • Pages.535-540
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  • 2012
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Biological Evaluation of N-(Aminopyridine) Benzamide Analogues as Histone Deacetylase Inhibitors

  • Zhang, Qing-Wei (State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China Pharmaceutical Industry Research Institute) ;
  • Li, Jian-Qi (State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China Pharmaceutical Industry Research Institute)
  • 투고 : 2011.10.19
  • 심사 : 2011.12.08
  • 발행 : 2012.02.20
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초록

A series of benzamide-based histone deacetylases (HDACs) inhibitors possessing N-(aminopyridine) residue as the zinc binding site of HDAC were synthesized and evaluated. Among these derivatives, compounds with N-(2-amino-4-pyridine) benzamide moiety have been found as the most potent ones. Moreover, introduction of appropriate substituents on the terminal aryl group acting as the surface-recognition domain could significantly improve the antiproliferative activity. In particular, the compound 4k possessed favorable pharmacokinetic characteristics and exhibited potent antitumor activity on xenograft model in mice at well tolerated doses, thus suggesting a good therapeutic index.

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피인용 문헌

  1. Thermodynamic Characteristics and Spectral-Luminescent Properties of N-m-Tolylbenzamide in Microheterogeneous Surfactant Self-Assemblies vol.43, pp.3, 2014, https://doi.org/10.1007/s10953-014-0151-x
  2. Design, synthesis and biological evaluation of novel coumarin-based benzamides as potent histone deacetylase inhibitors and anticancer agents vol.132, pp.None, 2012, https://doi.org/10.1016/j.ejmech.2017.03.024
  3. Discovery of quinazolinyl-containing benzamides derivatives as novel HDAC1 inhibitors with in vitro and in vivo antitumor activities vol.117, pp.None, 2012, https://doi.org/10.1016/j.bioorg.2021.105407