Bulletin of the Korean Chemical Society

  • 제33권1호
  • /
  • Pages.128-136
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  • 2012
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Solid-phase Parallel Synthesis of a Novel N-[Alkylsulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted Amide and Amine Drug-like Libraries

  • Kim, Ji-Hye (Center for Innovative Drug Library Research, Department of Chemistry, Dongguk University) ;
  • Gong, Young-Dae (Center for Innovative Drug Library Research, Department of Chemistry, Dongguk University) ;
  • Lee, Gee-Hyung (Center for Innovative Drug Library Research, Department of Chemistry, Dongguk University) ;
  • Seo, Jin-Soo (Center for Drug Discovery Platform Technology, Korea Research Institute of Chemical Technology)
  • 투고 : 2011.11.01
  • 심사 : 2011.11.11
  • 발행 : 2012.01.20
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초록

We report the solid-phase library construction of 222 number of a novel N-[alkyl sulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted amide 1A and amine 1B derivatives. The polymer-bound N-[alkylsulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted amide 9 and amine 10 derivatives were obtained by first diversity generation with various acid chlorides and alkyl halides. Further reactions on the resins 9 and 10 with substituted sulfonyl chlorides produced the desired N-[alkylsulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted amide 1A and amine 1B analogues.

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피인용 문헌

  1. Solid-Phase Parallel Synthesis of Drug-Like Artificial 2H-Benzopyran Libraries vol.17, pp.5, 2012, https://doi.org/10.3390/molecules17055467
  2. Discovery of a Novel 2,6-Difunctionalized 2H-Benzopyran Inhibitors Toward Sphingosylphosphorylcholine Synthetic Pathway as New Anti-inflammatory Target vol.35, pp.8, 2012, https://doi.org/10.5012/bkcs.2014.35.8.2385