Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Inhibitory Effect of 4-Aryl 2-Substituted Aniline-thiazole Analogs on Growth of Human Prostate Cancer LNCap Cells

  • Baek, Seung-Hwa (Pharmacology Research Center, Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Kim, Nak-Jeong (Metabolic Syndrome Therapeutics Research Center, Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Kim, Seong-Hwan (Pharmacology Research Center, Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Park, Kwang-Hwa (Department of Pathology, Yonsei University Wonju College of Medicine) ;
  • Jeong, Kyung-Chae (Molecular Oncology Branch, National Cancer Center) ;
  • Park, Bae-Keun (Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine) ;
  • Kang, Nam-Sook (Graduate School of New Drug Discovery and Development, Chungnam National University)
  • Received : 2011.08.30
  • Accepted : 2011.11.07
  • Published : 2012.01.20
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Abstract

Androgen receptor (AR) is ligand-inducible nuclear hormone receptor which has been focused on key molecular target in growth and progression of prostate cancer. We synthesized a series of 4-aryl 2-substituted aniline-thiazole analogs and evaluated their anti-cancer activity in AR-dependent human prostate cancer LNCap cells. Among them, the compound 6 inhibited the tumor growth in LNCap-inoculated xenograft model.

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References

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