Korean Journal of Radiology

  • 제13권4호
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  • Pages.434-442
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  • 2012
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
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DOI QR코드

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Spectral CT: Preliminary Studies in the Liver Cirrhosis

  • Lv, Peijie (Department of Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Lin, Xiaozhu (Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine) ;
  • Gao, Jianbo (Department of Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Chen, Kemin (Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine)
  • 발행 : 2012.08.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: To investigate the value of spectral CT imaging in the diagnosis and classification of liver cirrhosis during the arterial phase (AP) and portal venous phase (PVP). Materials and Methods: Thirty-eight patients with liver cirrhosis (Child-Pugh class A/B/C: n = 10/14/14), and 43 patients with healthy livers, participated in this study. The researchers used abdominal spectral CT imaging during AP and PVP. Iodine concentration, derived from the iodine-based material-decomposition image and the iodine concentration ratio ($IC_{ratio}$) between AP and PVP, were obtained. Statistical analyses {two-sample t test, One-factor analysis of variance, and area under the receiver operating characteristic curve (A [z])} were performed. Results: The mean normalized iodine concentration (NIC) (0.5 ${\pm}$ 0.12) during PVP in the control group was significantly higher than that in the study group (0.4 ${\pm}$ 0.10 on average, 0.4 ± 0.08 for Class A, 0.4 ${\pm}$ 0.15 for Class B, and 0.4 ${\pm}$ 0.06 for Class C) (All p < 0.05). Within the cirrhotic liver group, the mean NIC for Class C during the AP (0.1 ${\pm}$ 0.05) was significantly higher than NICs for Classes A (0.1 ${\pm}$ 0.06) and B (0.1 ${\pm}$ 0.03) (Both p < 0.05). The $IC_{ratio}$ in the study group (0.4 ${\pm}$ 0.15), especially for Class C (0.5 ${\pm}$ 0.14), was higher than that in the control group (0.3 ${\pm}$ 0.15) (p < 0.05).The combination of NIC and $IC_{ratio}$ showed high sensitivity and specificity for differentiating healthy liver from cirrhotic liver, especially in Class C cirrhotic liver. Conclusion: Spectral CT Provides a quantitative method with which to analyze the cirrhotic liver, and shows the potential value in the classification of liver cirrhosis.

키워드

참고문헌

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