The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Lactic Acidosis Caused by Linezolid Treatment of Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia

지속적인 메티실린 내성 황색포도알균 균혈증에 대한 Linezolid 치료 중 발생한 젖산 산증 1예

  • Kim, Yu-Seok (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine) ;
  • Kim, Ji-Beom (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine) ;
  • Lee, Yu-Mi (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine) ;
  • Kim, Sung-Han (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine) ;
  • Choi, Sang-Ho (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine) ;
  • Woo, Jun-Hee (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine) ;
  • Kim, Yang-Soo (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine)
  • 김유석 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김지범 (울산대학교 의과대학 서울아산병원 내과) ;
  • 이유미 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김성한 (울산대학교 의과대학 서울아산병원 내과) ;
  • 최상호 (울산대학교 의과대학 서울아산병원 내과) ;
  • 우준희 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김양수 (울산대학교 의과대학 서울아산병원 내과)
  • Published : 2012.04.01
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Abstract

Linezolid is an antibiotic in the oxazolidinone family that works as a bacterial protein synthesis inhibitor. It is used for the treatment of Gram-positive, multidrug-resistant bacteria. Adverse effects of linezolid include bone marrow suppression, peripheral or optic neuropathy, and, less commonly, lactic acidosis. Lactic acidosis usually occurs as a result of cardiopulmonary failure or sepsis, but it is sometimes caused by drugs, such as linezolid, and treatment of such lactic acidosis involves cessation of the drug. We report a case of lactic acidosis caused by the use of linezolid for the treatment of persistent methicillin-resistant Staphylococcus aureus bacteremia, which occurred after endoscopic sclerotherapy of gastic varices.

위 정맥류에 대한 내시경적 경화요법 이후에 위 정맥류에 발생한 패혈성 혈전 정맥염이 원발병소인 지속적인 MRSA 균혈증에서 linezolid 사용 중에 발생한 젖산 산증 1예를 경험하였기에 보고하는 바이다.

Keywords

References

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