The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지
DOI QR코드

DOI QR Code

Quadruple Mtachronous Primary Neoplasms in the Aerodigestive Tract

소화기계 및 호흡기계에 발생한 이시성 4중복암

  • Kim, Yong-Hyun (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Park, Keon-Woo (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Lee, Soon-Il (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Lim, Do-Hyoung (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Lee, Hyun-Suk (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Hyun, Kyung-Hee (Department of Internal Medicine, Dankook University College of Medicine)
  • 김용현 (단국대학교 의과대학 내과학교실) ;
  • 박건우 (단국대학교 의과대학 내과학교실) ;
  • 이순일 (단국대학교 의과대학 내과학교실) ;
  • 임도형 (단국대학교 의과대학 내과학교실) ;
  • 이현숙 (단국대학교 의과대학 내과학교실) ;
  • 현경희 (단국대학교 의과대학 내과학교실)
  • Published : 2012.01.01
⟨ Previous Next ⟩

Abstract

Multiple primary neoplasms, defined as the occurrence of multiple malignant neoplasms in the same individual, were first reported by Billroth in 1889. With gradual improvements in diagnostics, and the early detection and effective treatment of malignant neoplasms, the prevalence of multiple primary neoplasms seems to be increasing. Although there have been several reports of triple primary neoplasms in Korea, cases of quadruple neoplasms are rare. Recently, we diagnosed a 69-year-old male with primary neoplasms in the lung, esophagus, vocal cords, and hypopharynx. The authors report this rare case of four metachronous primary neoplasms and provide a review of the literature.

한 사람에서 다발성으로 악성종양이 발생하는 다발 원발암은 1889년 Billroth에 의해 처음 발표되었다. 최근 들어 악성종양에 대한 점진적인 진단 및 치료기술의 발달로 다발원발암의 발생률은 증가되는 추세이다. 국내에서도 3중복암에 대한 몇몇 증례 보고가 있었으나 4중복암에 대한 발표는 드물다. 최근 저자들은 69세 남자에게서 발생한 이시성 4중복암-폐, 식도, 성문, 하인두-을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. Lopez Molla C, Estelles Ferriol E, Carrasco Llatas M, et al. Malignant multiple neoplasms in head and neck squamous cell carcinoma. Acta Otorrinolaringol Esp 2008;59:427-432. https://doi.org/10.1016/S0001-6519(08)75113-6
  2. Warren S, Gates O. Multiple primary malignant neoplasm. Cancer 1932;16:1358.
  3. Cheng HY, Chu CH, Chang WH, et al. Clinical analysis of multiple primary malignancies in the digestive system: a hospital-based study. World J Gastroenterol 2005;11:4215-4219. https://doi.org/10.3748/wjg.v11.i27.4215
  4. Hong SW, Nah YW, Kang YK, Lee HS. A case of four metachronous primary malignant tumors. Inje Med J 1999;20: 553-557.
  5. Sohn WY, Wang HJ, Suh KW, Kim MW. Four primary cancers in abdominal cavity. J Korean Surg Soc 1997;53:921-926.
  6. Bae JM, Kim SW, Kim SW, Song SK. Metachronous four primary malignancies in gastro-intestinal tract. Korean J Gastroenterol 2009;53:373-377. https://doi.org/10.4166/kjg.2009.53.6.373
  7. Rosso S, Terracini L, Ricceri F, Zanetti R. Multiple primary tumours: incidence estimation in the presence of competing risks. Pop Health Metrics 2009;7:5. https://doi.org/10.1186/1478-7954-7-5
  8. Hayat MJ, Howlader N, Reichman ME, Edwards BK. Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist 2007;12:20-37. https://doi.org/10.1634/theoncologist.12-1-20
  9. Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer 1953;6:963-968. https://doi.org/10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q
  10. Braakhuis BJ, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH. A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 2003;63:1727-1730.

Cited by

  1. Quadruple Metachronous Primary Malignant Neoplasm in the Head and Neck and Digestive Tract vol.92, pp.2, 2012, https://doi.org/10.3904/kjm.2017.92.2.204