The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effects of SBD-1 on Hangover Syndrome : a Randomized Double-blind Crossover Preliminary Study

신선불취단(神仙不醉丹) 가감방(加減方)의 숙취 예방효과에 대한 이중맹검 무작위배정 교차임상 예비연구

  • Jeong, Hyun-Suk (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Kang, Sei-Young (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Han, Hyun-Jin (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Jang, In-Soo (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University)
  • 정현숙 (우석대학교 한의과대학 한방내과학교실) ;
  • 강세영 (우석대학교 한의과대학 한방내과학교실) ;
  • 한현진 (우석대학교 한의과대학 한방내과학교실) ;
  • 장인수 (우석대학교 한의과대학 한방내과학교실)
  • Published : 2012.12.30
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Abstract

Objectives : This study investigated the effect of Sinseonbulchuidan (SBD-1) on hangover syndrome. We undertook this study to test whether SBD-1 is effective in preventing the signs and symptoms of alcohol-induced hangover. Methods : Fifteen healthy volunteers participated in this double-blind randomized crossover study. All participants received either SBD-1 or indistinguishable placebo capsules before alcohol consumption. The primary outcome measure was the difference in hangover severity scores between SBD-1 and placebo intervention. Secondary outcome measure was the difference in profile of mood states (POMS) between SBD-1 and placebo intervention. Results : After alcohol exposure, the overall symptom scores were significantly decreased in the SBD-1 group compared with those given a placebo. The mean scores for the hangover symptoms were high in the placebo group, and statistical significance was observed in 4 symptom scores (loss of appetite, stomachache, nausea, and total score). There were no differences in the POMS and cognitive performance test results between SBD-1 and placebo intervention. Conclusions : We conclude that the SBD-1 is effective in preventing the signs and symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.

Keywords

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