대한본초학회지 (The Korea Journal of Herbology)

  • 제27권1호
  • /
  • Pages.1-10
  • /
  • 2012
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
DOI QR코드

DOI QR Code

기혈관절방(氣血關節方)A(CWS-A)가 CFA로 유발(誘發)된 관절염(關節炎)에 미치는 영향(影響)

The effect of Gihyeolgwanjeolbang-A(CWS-A) on adjuvant-induced arthritis in rats

  • 나창수 (동신대학교 한의과대학 경혈학교실) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 김정상 (동신대학교 한의과대학 해부학교실) ;
  • 채우석 (동신대학교 한의과대학 침구학교실)
  • Na, Chang-Su (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University) ;
  • Youn, Dae-Hwan (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University) ;
  • Kim, Jeong-Sang (Dept. of Anatomy, Oriental Medical School, Dongshin University) ;
  • Chae, Woo-Seok (Dept. of Acupuncture, Oriental Medical School, Dongshin University)
  • 투고 : 2011.12.15
  • 심사 : 2012.01.13
  • 발행 : 2012.01.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective : To investigate effects of herbal preparations formulated(Gihyeolgwanjeolbang-A, CWS-A) on complete Freund's adjuvant (CFA)-induced arthritis in rats. Method : Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw, and the herbal preparations formulated(CWS-A I, 82.3 mg/kg ; CWS-A II, 164.6 mg/kg) was administered orally (i.g.) for 10 consecutive days beginning on day 10 after the injection. External shape, paw edema, inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), and histological observation were assessed. Result : In swelling of the paw, CWS-A I and CWS-A II group in 15 days and 20 days were significantly reduced compared to controls. In serum ALT, CWS-A I and CWS-A II group were significantly reduced compared to controls. In TNF-${\alpha}$, CWS-A I and CWS-A II group were a tendency reduced compared to controls. In HGB, HCT, MCHC of erythrocytes, CWS-A II group was increased compared to controls. In histological observations, CWS-A II group was observed synoviocytes more than control group and was observed proteoglycans in the deep layers. Conclusion : The data suggest that CWS-A significant anti-arthritic effects that may be mediated by suppressing inflammatory parameters.

키워드

참고문헌

  1. Naver dictionary. http://terms.naver.com/entry.nhn?docId=487442
  2. Korean Orthopaedic Association. Orthopaedics. Seoul:Newest Medicine Company. 2001:123-31, 175-89.
  3. Compilation Committee for Translation Harrison. Harrison's principles of international medicine. Seoul:Jeongdam company. 2006:78-99.
  4. The Korean Academy of Oriental Rehabilitation Medicine. Oriental Rehabilitation Medicine. Seoul: Kooja company. 2005:97-9.
  5. Yonghun Choi. An Analysis of the Study Tendency on Rheumatoid Arthritis and its Treatment. Daejeon University Graduate school. 2009.
  6. Pearson CM. Development of arthritis, periarthritis and periostitis in rats given adjuvant. Proceedings of the society for experimental biology and medicine. 1956;91(1):95-101. https://doi.org/10.3181/00379727-91-22179
  7. Byungchan Bae. Soppress Effects of Imyosan on Freund's Complete Adjuvant-Induced Arthritic Rats. DaeguHaany University Graduate School. 2011.
  8. Sunmo Yun. Suppress Effects of So-Whal-Rack-Dan on Freund's Complete Adjuvant-Induced Arthritic Rats. DaeguHaany University Graduate School. 2010.
  9. Dukhee Kim. Inhibiting Effects of Hwallak-dan on the Adjuvant-Induced Arthritis in Lewis Rats. Semyung University Graduate School. 2009.
  10. Byungsun Je. (The) study on the effects of Dang-gui-cheon-gung- tang-ka-mi-bang on the arthritis. Daejeon University Graduate School. 2005.
  11. Duksoon Hwang. Effects of Kagammokbanggi-Tang on the Adjuvant-Induced Arthritis in Rats. Semyung University Graduate School. 2005.
  12. Jaeuk Sul. Experimental effects of Mahwangkanghwal-Tang on the adjuvant arthritis in rats. Dongshin University Graduate School . 2005.
  13. James B Wyngeeden. Cecil Textbook of Medicine. Philadelphia. WA Sauders company. 1992:1508-15.
  14. Brahn E, Peacock DJ, Banquerigo ML, Liu DY. Effects of tumor necrosis factor alpha (TNF-alpha) on collagen arthritis. Lymphokine Cytokine Res. 1992;11(5):253-6.
  15. Dolhain RJ, van der Heiden AN, ter Haar NT, Breedveld FC, Miltenburg AM. Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum. 1996;39(12):1961-9. https://doi.org/10.1002/art.1780391204
  16. Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis:what have we learned? Annu Rev Immunol. 2001;19:163-96. https://doi.org/10.1146/annurev.immunol.19.1.163
  17. Iwai H, Kozono Y, Hirose S, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M. Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. J Immunol. 2002;169(8):4332-9. https://doi.org/10.4049/jimmunol.169.8.4332
  18. Yugyul Yang. Huangjenaegyeongsomunseokhae(黃帝內經素問釋解). Seoul:Iljung Company. 1991:328.
  19. Jungkyung Jang. Jingguiyaolue(金匱要略). Taiwan:Daeryungulpung Company. 1973:32-3.
  20. Gaebin Jang. Complete Works of Zhang Jingyue(景岳全書). Seoul:Hanglimseowon. 1975:153-9.
  21. Jesik Kwon. Bi-syndrome(痺證). Seoul:Jeongdam company. 1993:23-9.
  22. Jungheui Lee, Taewon Song, Minseok Oh. Analysis of the herb medications corresponded with Bi-jeung of Bangyakhappyeon. J Institute of Oriental Medicine of Daejeon University. 2001:10(1):375-83.
  23. Mingyu Shin. Clinical Herbal-Medicine. Seoul:Younglim Company. 2006:194-6, 209-10, 204-5, 236-9, 240-2, 385-7, 405-7, 477-8, 479-80, 497-8, 517-8, 519-21, 525-7, 654-7, 731-2, 736-7.
  24. Deoggyun An et al. The Encyclopedia of Chinese Medicine. Seoul:Jeongdam company. 1998: 141-7, 393-7, 1036-43, 1117-26, 1159-68, 1451-5, 2020-2, 2179-83, 2769-75, 4177-86, 4418-25, 6124-30, 6460-71, 6512-25.
  25. YongRe Chung, SeungDeok Lee, Hyuk Byun, InShik Park, ChanYung Jung, ChangHwan Lee, KapSung Kim. The Effect of Deer Antler Herbal Acupuncture Control to Hyper-inflammatory Responses on Synovial Membrane by LPS-induced Arthritis. J Korean Acupuncture & Moxibustion Society. 2007;24(4):167-81.
  26. YongKi Park, ByungSoo Kang. Studies on the Effects of Coicis Semen and Sophorae Radix onthe Antioxidation. Kor J Herbology. 2000;15(2):57-67.
  27. Ill-Yun Jeong, Joo-Sang Lee, Heon Oh, Uhee Jung, Hae-Ran Park, Sung-Kee Jo. Inhibitory Effect of Hot-Water Extract of Paeonia japonica on Oxidative Stress and Identification of Its Active Components. Journal of the Korean Society of Food Science and Nutrition. 2003;32(5):739-44. https://doi.org/10.3746/jkfn.2003.32.5.739
  28. EunYoung Hwang, DongHee Kim, HuiJeong Kim, JoYoung Hwang, TaeSoon Park , InSun Lee, Jun Ho Son. Antioxidant Activities and Nitric Oxide Production of Medicine Plants in Gyeongsangbukdo (Carthamus tinctorius seed, Cyperus rotundus, Schizonepeta tenuifolia, Polygonatum odoratum var. pluriflorum, Paeonia lactiflora). Journal of Applied Biological Chemistry. 2011;54(3):171-7. https://doi.org/10.3839/jabc.2011.029
  29. HyunJin Kim, JungWon Lee, YongDoo Kim. Antimicrobial Activity and Antioxidant Effect of Curcuma longa, Curcuma aromatica and Curcuma zedoaria. Korean J Food Preservation. 2011;18(2):219-25. https://doi.org/10.11002/kjfp.2011.18.2.219
  30. JongCheng Mou, SeNa Lee, MyungGyou Kim, MyoungHee Kim, HyungJun Kim, HakJun Jo, KangHyun Leem. Effects of Astragali Radix Extracts on the Elastase Activity and DPPH and NO Scavenging Activities. Kor J Herbology. 2011;26(1):59-63.
  31. ByeongSu Kim, YeonSeob Kim. Effect of Corydalidis Tuber, Paeoniae Radix Rubra, Carthami Flos Complex Herbal Acupuncture on Inflamation and Liver in Rats with Arthritis induced by Freund's Complete Adjuvant. Kor J Herbology. 2004;19(1):95-102.
  32. JungHwa Kim, DaeHo Kim, JinHyun You, CheolHee Kim, MinChul Kwon, NakSul Seong, SeungEun Lee, HyeonYong Lee. Immuno-regulatory Activities of Various Fractions from Ehpedrae Sinica STAPF, Rubus Coreanus Miq. and Angelica gigas Nakai Extracts. Korean Journal of Medicinal Crop Science. 2005;13(4):161-170.
  33. Suna Kang, Gihyo Jang, Jieun Lee, Deoggyun An, Seonggyu Park. Differences of Hematopoietic Effects of Angelica gigas, A. sinensis and A. acutiloba Extract on Cyclophosphamide-induced Anemic Rats. Korean J Food Sci Technol. 2003;35(6):1204-8.
  34. Kuinyung Lee, Jongsun Lee. Clinical pathology files. Seoul:Medical culture Company. 1990:82-7, 740-1.
  35. Kuinyung Lee, Haeran Moon, Eunhee Lee. Lab Test 2000 Directory. Seoul:Korea Medicine Company. 1998:71-4.
  36. Yaron I, Meyer FA, Dayer JM, Yarom M. Human recombinant interleukin-1 beta stimulates glycosaminoglycan production in human synovial fibroblast cultures. Arthritis and rheumatism. 1987;30(4):424-30. https://doi.org/10.1002/art.1780300410
  37. Tehyun Yoon, Sangkeun Oh. A Histopathological Study on the Rheumatoid Arthritis of the Knee Joint. J Korean Orthop Assoc. 1981:16(3):528-38.
  38. Lee Moonho et al. Internal Medicine. Seoul:Haklim Company. 1986:1693-727.