Communications for Statistical Applications and Methods

  • 제19권1호
  • /
  • Pages.33-45
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  • 2012
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  • 2287-7843(pISSN)
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  • 2383-4757(eISSN)
한국통계학회 (The Korean Statistical Society)
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다중 그룹 상황에서의 최소 효과 용량을 정하는 비모수적 검정법

Nonparametric Procedures for Finding the Minimum Effective Dose in Each of Several Group

  • 배수현 (가톨릭대학교 대학원 의학통계학과) ;
  • 김동재 (가톨릭대학교 대학원 의학통계학과)
  • Bae, Su-Hyun (Department of Biostatistics, The Catholic University) ;
  • Kim, Dong-Jae (Department of Biostatistics, The Catholic University)
  • 투고 : 20110900
  • 심사 : 20111100
  • 발행 : 2012.01.30
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⟨ 이전 논문 다음 논문 ⟩

초록

신약 개발 연구 또는 임상시험에서 개발된 약이 0용량 대조군과 비교해 효과 차이가 있는 가장 작은 용량을 최소 효과 용량(MED)이라 한다. 본 논문에서는 다중 그룹 상황에서 동시적(simultaneous)으로 각 각 그룹의 최소 효과 용량을 확인하기 위하여 위치(placement)에 기초한 비모수적 방법을 제시하였다. 또한 Monte Carlo 모의실험을 통하여 기존에 제시된 검정법과 본 논문에서 제안한 검정법의 검정력(power)과 FWE(Family-wise Error Rate)를비교하였다.

The primary interest of drug development studies is to estimate the smallest dose that shows a significant difference from the zero-dose control. The smallest dose is called the Minimum Effective dose(MED). In this paper, we suggest a nonparametric procedure to simultaneously find the MED of each group based on placements. The Monte Carlo simulation is adapted to estimate the power and the family-wise error rate(FWE) of the new procedures with those of discussed nonparametric tests to find MED.

키워드

참고문헌

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