Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Clinical Impact of Non-High Density Lipoprotein-Cholesterol and Apolipoprotein B on Clinical Outcomes in Metabolic Syndrome Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

  • Ahmed, Khurshid (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Jeong, Myung-Ho (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Chakraborty, Rabin (Apollo Gleneagles Hospital) ;
  • Hong, Young-Joon (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Oh, Mi-Sook (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Cho, Kyung-Hoon (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kim, Min-Chol (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Hachinohe, Daisuke (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Hwang, Seung-Hwan (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Lee, Min-Goo (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Sim, Doo-Sun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Park, Keun-Ho (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kim, Ju-Han (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Ahn, Young-Keun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kang, Jung-Chaee (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences)
  • Published : 2012.05.31
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Abstract

Background and Objectives: Non-high density lipoprotein-cholesterol (non-HDL-C) and apolipoprotein B (ApoB) are markers of atherosclerotic risk and predictors of cardiovascular events. The aim of this study was to evaluate clinical impact of non-HDL-C and ApoB on clinical outcomes in metabolic syndrome (MS) patients with acute myocardial infarction (AMI) undergoing percuatneous coronary intervetion. Subjects and Methods: We analyzed 470 MS patients ($64.4{\pm}12.0$ years, 53.6% male) with AMI who were followed-up for 12-month after percutaneous coronary intervention (PCI) from December 2005 to January 2008 in a single center. These patients were divided into 2 groups based on median values of non-HDL-C and ApoB. We studied their baseline and follow-up relation with 12-month clinical outcomes, all-cause death and major adverse cardiac events (MACE). Results: Mean values of baseline non-HDL-C and ApoB were $141.2{\pm}43.1\;mg/dL$ and $99.3{\pm}29.0\;mg/dL$ respectively. During 12-month follow-up 32 MACE (6.8%) and 12 deaths (2.5%) occurred. We observed significant correlation between non-HDL-C and ApoB. Twelve-month MACE and all-cause death after PCI showed no significant relation as non-HDL-C or ApoB levels increased. Follow-up patients (n=306, rate 65%) also did not show significant relation with clinical outcomes. Twelve-month MACE decreased as non-HDL-C and ApoB reduction rates increased. Conclusion: There was no significant association between higher non-HDL-C or ApoB and 12-month clinical outcomes in MS patients with AMI undergoing PCI. ApoB was found to be a better predictor of 12-month MACE than non-HDL-C based on their reduction rates.

Keywords

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