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Malignant Melanoma of Unknown Primary Origin Presenting as Cardiac Metastasis

  • Lee, Eun-Young (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Choi, Jin-Oh (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Park, Ha-Na (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Park, Eun-Jung (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Lee, Gil-Sun (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Park, Jun-Young (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Kim, Jung-Sun (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Jeon, Eun-Seok (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center)
  • Published : 2012.04.30

Abstract

Malignant melanoma has a very high propensity to metastasize to the heart. However, melanoma may sometimes present as a metastatic lesion in the absence of a primary lesion, which are called melanomas of unknown primary origin. We report a case in which a patient presented with a metastatic maligant melanoma in the right atrium with pericardial effusion and without a primary origin.

Keywords

References

  1. Ozyuncu N, Sahin M, Altin T, Karaoguz R, Guldal M, Akyurek O. Cardiac metastasis of malignant melanoma: a rare cause of complete atrioventricular block. Europace 2006;8:545-8. https://doi.org/10.1093/europace/eul058
  2. MacGee W. Metastatic and invasive tumours involving the heart in a geriatric population: a necropsy study. Virchows Arch A Pathol Anat Histopathol 1991;419:183-9. https://doi.org/10.1007/BF01626346
  3. Savoia P, Fierro MT, Zaccagna A, Bernengo MG. Metastatic melanoma of the heart. J Surg Oncol 2000;75:203-7. https://doi.org/10.1002/1096-9098(200011)75:3<203::AID-JSO9>3.0.CO;2-X
  4. Malouf JF, Thompson RC, Maples WJ, Wolfe JT. Diagnosis of right atrial metastatic melanoma by transesophageal echocardiographic-guided transvenous biopsy. Mayo Clin Proc 1996;71:1167-70. https://doi.org/10.4065/71.12.1167
  5. Qu G, Kaur JS, Seward JB. Metastatic melanoma presenting as cardiac mass and hemobilia. Am J Med Sci 2003;325:157-9. https://doi.org/10.1097/00000441-200303000-00009
  6. Basarici I, Demir I, Yilmaz H, Altekin RE. Obstructive metastatic malignant melanoma of the heart: imminent pulmonary arterial occlusion caused by right ventricular metastasis with unknown origin of the primary tumor. Heart Lung 2006;35:351-4. https://doi.org/10.1016/j.hrtlng.2005.11.001
  7. Chang AE, Karnell LH, Menck HR. The national cancer data base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade: the American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998;83:1664-78. https://doi.org/10.1002/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G
  8. Lee KS. Resection of cardiac metastasis of malignant melanoma. Korean Circ J 2000;30:1170-4.
  9. Kim OG, Hong JM, Lee SJ, Hong JS. Cardiac metastasis of malignant melanoma: a case report. Korean J Thorac Cardiovasc Surg 1999;32:840-3.
  10. Baab GH, McBride CM. Malignant melanoma: the patient with an unknown site of primary origin. Arch Surg 1975;110:896-900. https://doi.org/10.1001/archsurg.1975.01360140040008
  11. Schlagenhauff B, Stroebel W, Ellwanger U, et al. Metastatic melanoma of unknown primary origin shows prognostic similarities to regional metastatic melanoma: recommendations for initial staging examinations. Cancer 1997;80:60-5. https://doi.org/10.1002/(SICI)1097-0142(19970701)80:1<60::AID-CNCR8>3.0.CO;2-J
  12. Katz KA, Jonasch E, Hodi FS, et al. Melanoma of unknown primary: experience at Massachusetts General Hospital and Dana-Farber Cancer Institute. Melanoma Res 2005;15:77-82. https://doi.org/10.1097/00008390-200502000-00013
  13. Manola J, Atkins M, Ibrahim J, Kirkwood J. Prognostic factors in metastatic melanoma: a pooled analysis of Eastern Cooperative Oncology Group Trials. J Clin Oncol 2000;18:3782-93. https://doi.org/10.1200/JCO.2000.18.22.3782
  14. Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 2001;19: 3622-34. https://doi.org/10.1200/JCO.2001.19.16.3622

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