The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Linezolid-Associated Lactic Acidosis

Linezolid에 의한 유산증 1예

  • Lee, Hong-Joo (Department of Internal Medicine, Kyung Hee University College of Medicine) ;
  • Choi, Jae-Ho (Department of Internal Medicine, Kyung Hee University College of Medicine) ;
  • Kim, Sun-Yong (Department of Internal Medicine, Kyung Hee University College of Medicine) ;
  • Chung, Kyung-Hwan (Department of Internal Medicine, Kyung Hee University College of Medicine) ;
  • Lee, Tae-Won (Department of Internal Medicine, Kyung Hee University College of Medicine) ;
  • Ihm, Chun-Gyoo (Department of Internal Medicine, Kyung Hee University College of Medicine) ;
  • Moon, Ju-Young (Department of Internal Medicine, Kyung Hee University College of Medicine)
  • 이홍주 (경희대학교 의과대학 내과학교실) ;
  • 최재호 (경희대학교 의과대학 내과학교실) ;
  • 김선용 (경희대학교 의과대학 내과학교실) ;
  • 정경환 (경희대학교 의과대학 내과학교실) ;
  • 이태원 (경희대학교 의과대학 내과학교실) ;
  • 임천규 (경희대학교 의과대학 내과학교실) ;
  • 문주영 (경희대학교 의과대학 내과학교실)
  • Published : 2012.03.01
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Abstract

Linezolid has been used for treatment of vancomycin-resistant Enterococcus faecium infection, nosocomial pneumonia caused by Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus or Streptococcus pneumoniae, and complicated and uncomplicated skin and skin structure infections. Lactic acidosis is an adverse effect associated with drugs, including metformin, the nucleoside reverse-transcriptase inhibitors and, rarely, linezolid. We report a case in which severe lactic acidosis developed as an adverse effect of linezolid in a 75-year-old woman who had been on linezolid for 30 days for treatment of a wound infection caused by methicillin-resistant coagulase-negative Staphylococcus. Discontinuation of linezolid and hemodialysis improved her lactic acidosis.

Keywords

References

  1. Bain KT, Wittbrodt ET. Linezolid for the treatment of resistant gram-positive cocci. Ann Pharmacother 2001;35:566-575.
  2. Bishop E, Melvani S, Howden BP, Charles PG, Grayson ML. Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients. Antimicrob Agents Chemother 2006;50:1599-1602. https://doi.org/10.1128/AAC.50.4.1599-1602.2006
  3. Velez JC, Janech MG. A case of lactic acidosis induced by linezolid. Nat Rev Nephrol 2010;6:236-242. https://doi.org/10.1038/nrneph.2010.20
  4. Wiener M, Guo Y, Patel G, Fries B. Lactic acidosis after treatment with linezolid. Infection 2007;35:278-281. https://doi.org/10.1007/s15010-007-6302-x
  5. Chung SK, Jeon JS, Kim TH, et al. A case of lactic acidosis associated with prolonged linezolid therapy. Korean J Nephrol 2009;28:41-43.
  6. Narita M, Tsuji BT, Yu VL. Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome. Pharmacotherapy 2007;27:1189-1197. https://doi.org/10.1592/phco.27.8.1189
  7. Palenzuela L, Hahn NM, Nelson RP Jr, et al. Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis? Clin Infect Dis 2005;40:e113-e116. https://doi.org/10.1086/430441
  8. Fiaccadori E, Maggiore U, Rotelli C, et al. Removal of linezolid by conventional intermittent hemodialysis, sustained low-efficiency dialysis, or continuous venovenous hemofiltration in patients with acute renal failure. Crit Care Med 2004;32:2437-2442. https://doi.org/10.1097/01.CCM.0000147687.06808.92
  9. Carson J, Cerda J, Chae JH, Hirano M, Maggiore P. Severe lactic acidosis associated with linezolid use in a patient with the mitochondrial DNA A2706G polymorphism. Pharmacotherapy. 2007;27:771-774. https://doi.org/10.1592/phco.27.5.771
  10. Peters N, Jay N, Barraud D, et al. Metformin-associated lactic acidosis in an intensive care unit. Crit Care 2008;12:R149. https://doi.org/10.1186/cc7137

Cited by

  1. The risk factors of linezolid-induced lactic acidosis : A case report and review vol.97, pp.36, 2012, https://doi.org/10.1097/md.0000000000012114